Coagulation Analyzer Interference Detection and Channel Switching
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Solution Overview
Problem
Current coagulation analyzers face challenges with optical interference from hemolysis, jaundice, and lipemia, leading to increased complexity, cost, and reduced accuracy due to the need for both magnetic bead and optical test channels, which also affects the design and reagent usage.
Innovation Solution
A coagulation analyzer with a sample interference analysis module to determine if optical interference affects test results, transferring affected samples to a magnetic coagulation analysis module for accurate testing, using an analysis cup without particles for optical tests and with particles for magnetic tests, thereby reducing costs and improving reliability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If both magnetic bead method test channel and optical method test channel are equipped in the instrument, then the ability to handle interfered samples is improved, but the device complexity increases
Solution Approach 1:
The instrument is divided into two independent test channels: magnetic bead method test channel and optical method test channel. Each channel is equipped with dedicated analysis cups (with or without magnetic beads) and reagents, allowing them to operate independently. This segmentation enables the system to handle different sample types appropriately while maintaining modularity and reducing overall system complexity.
Solution Approach 2:
The system dynamically selects which test channel to use based on sample characteristics. The sample interference analysis module evaluates each sample and automatically directs it to the appropriate channel (magnetic bead for interfered samples, optical for normal samples), making the system adaptable without requiring fixed complex routing for all samples.
2Object-affected harmful factors
If analysis cup with magnetic bead is used for all tests, then the anti-interference capability is improved, but the cost of consumables increases
Solution Approach 1:
Magnetic beads are added locally only to analysis cups designated for the magnetic bead method test channel, not to all analysis cups. Normal samples tested via optical method use analysis cups without magnetic beads, while only interfered samples (hemolysis, jaundice, lipemia) tested via magnetic bead method receive magnetic beads. This localized application reduces consumable costs while maintaining anti-interference capability where needed.
3Adaptability or versatility
If analysis cup with magnetic bead is used for immunoturbidimetry and colorimetry tests, then the test transfer capability is improved, but the reagent cost and measurement accuracy deteriorate
Solution Approach 1:
The system segments tests into two categories: coagulation items (tested via magnetic bead method when interfered) and immunoturbidimetry/colorimetry items (tested via optical method). Separate analysis cups and reagents are prepared for each category, preventing magnetic beads from interfering with non-coagulation tests and maintaining measurement accuracy for all test types.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces the frequency of using the magnetic module, lowers costs, maintains high accuracy and reliability, and improves economic efficiency by minimizing the use of magnetic bead-based instruments while maintaining anti-interference advantages.
Implementation Method 1
Based on the reaction principle of the immunoturbidimetry and colorimetry, optical method is usually used by the manufacturers for the testing
Implementation Method 2
The magnetic bead method uses magnetic force to drive a demagnetized steel bead (magnetically drivable particle in the context of the present invention) to move in the sample
Implementation Method 3
A steel bead particle displacement sensing device (usually a magnetic displacement sensing) is used to sense the movement of the demagnetized steel bead and calculate the clot time
Data Source
AI summary
The present invention discloses a coagulation analyzer and a coagulation analysis method which relate to the technical field of medical instruments. The coagulation analyzer includes an optical coagulation analysis module, a sample interference analysis module, a magnetic coagulation analysis module, and a test transfer module. The coagulation analyzer uses the sample interference analysis module to determine whether an interferent in the sample has effect on the coagulation test result of the optical coagulation analysis module. If the interferent in the sample has no effect on the coagulation test result, the optical coagulation analysis module is used to perform the coagulation analysis and report the test result. If the interferent in the sample has effect on the coagulation test result, the test transfer module is used to transfer the test to the magnetic coagulation analysis module to perform the coagulation analysis and report the test result.