Blood Coagulation Analyzer Multi-Wavelength Optical Determination
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Solution Overview
Problem
Existing blood coagulation analyzers require numerous samples for accurate determination of coagulation times, leading to reduced accuracy when the sample number is small, as they rely on actual measurements to establish a determination line separating normal from abnormal coagulation reactions.
Innovation Solution
The analyzer determines coagulation appropriateness based on optical properties at different wavelengths, analyzing the ratio or difference in light changes across wavelengths to assess coagulation advancement, reducing the need for extensive sample collection and simplifying the analysis process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a determination line based on actual measurements is used to separate normal from abnormal coagulation reactions, then the accuracy of coagulation time determination can be improved, but a large number of samples are required to be collected, increasing the complexity of the analysis process
Solution Approach 1:
The patent changes the parameter basis for determination from actual measurement data (requiring multiple samples) to optical property ratios at different wavelengths. By using the ratio of optical properties at first and second wavelengths, the system achieves accurate determination of coagulation appropriateness without requiring extensive sample collection, thus resolving the contradiction between measurement precision and process complexity
Solution Approach 2:
Instead of using actual measurement data from multiple samples to establish determination lines, the patent creates a virtual determination model based on optical property ratios. This copying approach uses the characteristic that optical properties differ by wavelength during coagulation, allowing accurate determination without physically collecting numerous samples
2Device complexity
If the number of samples collected is reduced, then the complexity of sample collection is decreased, but the accuracy of the determination line is reduced, leading to reduced accuracy of coagulation time determination
Solution Approach 1:
The patent fundamentally changes the determination parameter from statistical analysis of multiple actual measurements to real-time optical property ratio analysis. By monitoring how optical properties at different wavelengths change during coagulation and calculating their ratios, the system maintains high determination accuracy with minimal samples, effectively resolving this contradiction
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for accurate determination of coagulation times without requiring complex sample collection, improving accuracy and simplifying the analysis by using optical information from multiple wavelengths to assess coagulation progress.
Implementation Method 1
the obtaining section is configured to detect at least one of an intensity of light that has transmitted through the measurement specimen and an intensity of light that has been scattered by the measurement specimen
Implementation Method 2
a scattered light amount value is obtained by a measurement unit at a predetermined time interval
Data Source
Figure 1
Figure 2
Figure 3A~3C
AI summary
In order to improve accuracy of determination of a blood coagulation time without requiring complicated work, a measurement unit 2 of a blood coagulation analyzer 1 irradiates a measurement specimen prepared by mixing a blood specimen and a reagent together, with lights of a plurality of wavelengths including light of a wavelength λ1 and light of a wavelength λ2, obtains information regarding an amount of transmitted light that transmits through the measurement specimen, and transmits the obtained information to a control device 4. The control device 4 calculates a blood coagulation time of the blood specimen based on information regarding a transmitted light amount based on light of the wavelength λ1. Moreover, the control device 4 determines whether a blood coagulation time can be appropriately obtained through the measurement, based on information regarding transmitted light amounts based on light of wavelength λ1 and light of wavelength λ2.