Multi-Index Coagulation Detection System Using Microfluidic Test Cards
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Solution Overview
Problem
Conventional blood coagulation detection methods are costly, require complex equipment, and have unsatisfactory precision, making them time-consuming and inaccessible for frequent monitoring, especially for thrombosis patients who need continuous anticoagulation therapy.
Innovation Solution
A portable detection system for multi-index coagulation items that includes a housing with a detection and heating module, a touch display screen, and a mainboard, allowing for immediate, high-sensitivity testing without the need for professionals, using an AC impedance method and constant temperature control to analyze blood coagulation through a multi-channel microfluidic detection chip.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If conventional magnetic bead method or optical method is used for blood coagulation detection, then detection can be performed, but the equipment is complicated and costly
Solution Approach 1:
The patent segments the detection system into a simple handheld device with basic components (light source, detector, processor) and a separate test card containing the coagulation reagents and microfluidic channels. This segmentation allows the main device to remain simple and portable while the test card handles the complex biochemical reactions, resolving the contradiction between equipment simplicity and detection capability.
Solution Approach 2:
The patent replaces complex optical detection systems with a simpler light transmission/detection mechanism. Instead of using sophisticated optical analysis equipment, the system uses basic light sources and photodetectors to measure light transmission changes during coagulation, achieving reliable detection with minimal equipment complexity.
2Measurement precision
If conventional blood coagulation detection is performed in hospitals, then accurate detection can be achieved, but it takes long time and requires patient to go to hospital frequently
Solution Approach 1:
The patent implements self-service detection by enabling patients to perform coagulation tests at home using the handheld device and test cards. The device automatically performs the detection and processes results without requiring hospital visits, allowing patients to monitor their coagulation status conveniently at home while maintaining detection precision through standardized test cards and automated measurement protocols.
Solution Approach 2:
The test cards are pre-prepared with coagulation reagents and microfluidic channels configured for specific detection protocols. This preliminary preparation allows the device to perform detection immediately upon sample addition without requiring complex setup or calibration, achieving both high precision and rapid results within minutes.
3Reliability
If commercial blood coagulation analyzers are used, then detection can be performed, but the cost is high
Solution Approach 1:
The patent uses disposable test cards that contain pre-loaded reagents and microfluidic structures. These single-use test cards are inexpensive to manufacture and discard, eliminating the need for expensive, complex, and reusable analytical equipment. The low cost of disposable test cards maintains detection reliability while dramatically reducing overall system cost and complexity.
Solution Approach 2:
The patent creates simplified copies of hospital-grade coagulation detection capabilities in a handheld format. By replicating the essential detection functions using basic optical components and standardized test cards, the system achieves reliable detection at a fraction of the cost of commercial analyzers, making the technology accessible for home use.
4Ease of operation
If existing portable coagulation test cards are used, then some detection can be performed, but they cannot detect five coagulation items simultaneously and require sample preprocessing
Solution Approach 1:
The patent designs the handheld device and test card system to perform multiple coagulation detection functions (PT, APTT, TT, FIB, D-Dimer) using a single unified platform. The test cards are configured with multiple detection zones that can simultaneously analyze different coagulation parameters from one blood sample, eliminating the need for separate tests or complex sample preprocessing while expanding detection versatility.
Solution Approach 2:
The patent merges multiple detection functions into a single integrated test card and handheld device. Instead of requiring separate test cards or preprocessing steps for different coagulation parameters, the system combines all detection capabilities in one unit, allowing simultaneous measurement of five coagulation items from a single finger prick blood sample, greatly simplifying operation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, accurate, and cost-effective detection of multiple coagulation indices from fingertip blood samples within 8 minutes, reducing resource consumption and equipment complexity while maintaining high sensitivity and precision.
Implementation Method 1
constant temperature control to analyze blood coagulation
Implementation Method 2
The optical method is to determine the coagulation point by conducting optical analysis based on turbidity changes during blood coagulation
Implementation Method 3
using an AC impedance method and constant temperature control to analyze blood coagulation
Data Source
AI summary
A detection system for multi-index coagulation items, including a housing, a detection and heating module, a battery module, a touch display screen and a mainboard. The housing includes an upper housing and a lower housing, and is an enclosed space formed by the upper housing abutting the lower housing; the mainboard is disposed between the upper and the lower housing, and is arranged in the enclosed space; the touch display screen is disposed at the upper surface of upper housing, and is connected with the mainboard; the detection and heating module is disposed in the enclosed space, and is arranged at the front end of lower housing for connecting with the mainboard; the battery module is arranged at the bottom of terminal of lower housing, and is connected with the mainboard; and a detection inlet for inserting and placing a detection card is disposed at the front end of housing.