Coated Balloon Elastin Stabilization Phenolic Compound
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Solution Overview
Problem
Aneurysms pose a significant clinical challenge due to the degradation of arterial structural proteins like elastin, leading to vessel weakening and potential rupture, with existing treatments often invasive and carrying high risks.
Innovation Solution
A coated balloon device with a phenolic compound-based coating is deployed in the blood vessel to stabilize elastin, using a hydrophilic polymer binder and a phenolic compound that binds to elastin to prevent further degradation, combined with a hydrophilic undercoat layer and a sacrificial top coating for controlled drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments for aneurysms are used, then blood vessel stabilization can be achieved, but the procedures are invasive and carry high risks with longer recovery time
Solution Approach 1:
The phenolic compound coating is applied to the balloon surface before the procedure, preparing the therapeutic agent in advance for immediate delivery to the aneurysm site upon balloon inflation, eliminating the need for separate drug administration steps
Solution Approach 2:
The coated balloon acts as an intermediary device that delivers the phenolic compound directly to the blood vessel wall at the aneurysm site, mediating between the therapeutic agent and the target tissue while minimizing invasive intervention
2Reliability
If existing treatments for aneurysms are used, then blood vessel stabilization can be achieved, but recovery time is extended
Solution Approach 1:
The phenolic compound coating is pre-applied to the balloon, enabling immediate therapeutic action upon deployment without requiring separate medication administration or prolonged procedural steps that would extend recovery time
Solution Approach 2:
The procedure rapidly delivers the therapeutic phenolic compound to the target site through balloon inflation and deflation, skipping prolonged treatment phases and enabling quick patient recovery while achieving reliable vessel stabilization
3Reliability
If a coating layer with therapeutic composition is applied to the balloon, then elastin stabilization is improved, but the device complexity increases
Solution Approach 1:
The phenolic compound coating concentration and formulation parameters are optimized to achieve effective elastin stabilization with a simple two-layer coating structure, avoiding complex multi-component systems while maintaining therapeutic efficacy
Solution Approach 2:
The coating utilizes a composite structure with a phenolic compound therapeutic layer over a hydrophilic polymer undercoat, combining materials with complementary properties to achieve both drug delivery and balloon adhesion functions in a relatively simple layered system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coated balloon effectively stabilizes the blood vessel by inhibiting elastin degradation, providing mechanical strength and reducing the risk of rupture, while minimizing invasive procedures and recovery time.
Implementation Method 1
a phenolic compound that binds to elastin to prevent further degradation
Implementation Method 2
The coating can comprise a hydrophilic polymer binder and a therapeutic composition blended with the hydrophilic polymer
Implementation Method 3
The undercoat layer can be made porous to allow further hydration of the coating layer
Data Source
AI summary
A coated balloon device for stabilizing a section of a blood vessel in a living subject is disclosed. The coating layer of the coated balloon comprises a phenolic compound having a plurality of phenolic groups connected to form a hydrophobic core with peripheral phenolic hydroxyl groups. The coating layer of the coated balloon may contain a hydrophilic polymer to facilitate the release of the phenolic compound. The balloon in general is made of a compliant polymer for atraumatic contact with the blood vessel. In some embodiments, the coating of the coated balloon device further comprises a hydrophilic undercoat layer between the balloon and the coating layer. In some embodiments, the coated balloon device further comprises a sacrificial top coating that dissolves upon delivery into the section of the blood vessel and comprises a hydrophilic composition including sugar, sugar derivatives, or a combination thereof.