Coated Glass Element for Pharmaceutical Containers
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Solution Overview
Problem
Existing coated glass elements for pharmaceutical containers face challenges with stability and resistance, particularly at high pH values, leading to issues with the storage of sensitive pharmaceutical substances like biologics.
Innovation Solution
A coated glass container is developed with a coating process that includes surrounding the glass surface with a precursor and generating plasma through irradiation, with specific parameters such as process temperature and pulse duration optimized to achieve a stable and resistant coating.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a coating is applied to enhance glass surface resistance, then the resistance and stability of the glass surface is improved, but the stability of the coating at high pH values deteriorates
Solution Approach 1:
The patent applies plasma treatment with specific parameters (power density 0.1-10 W/cm², treatment time 1-60 minutes) to modify the glass surface properties. This changes the surface energy and chemical composition of the glass, creating a more stable surface that resists alkaline leaching without requiring additional coating materials that would compromise high pH stability.
Solution Approach 2:
The patent replaces chemical coating methods with physical plasma treatment. Instead of applying chemical coatings that may not be stable at high pH, the invention uses plasma energy to directly modify the glass surface structure, creating a stable, resistant surface through physical-chemical transformation rather than material deposition.
2Stability of the object's composition
If a coating is applied to protect the glass surface, then the chemical stability is improved, but the adhesion properties of the coating deteriorate
Solution Approach 1:
The plasma treatment is applied as a preliminary step before any coating process or directly to the glass surface. This pre-treatment modifies the glass surface properties (increasing surface energy, creating reactive groups) that enhance both chemical stability and subsequent coating adhesion, ensuring strong bonding while maintaining resistance to alkaline environments.
3Object-affected harmful factors
If a coating is applied to reduce alkali ion leaching, then the resistance to alkaline treatment is improved, but the manufacturing complexity increases
Solution Approach 1:
The patent extracts and eliminates the need for complex multi-layer coating systems by using plasma treatment to directly modify the glass surface. This single-step physical-chemical treatment achieves the same protective function as complex coatings, reducing manufacturing complexity while effectively preventing alkali ion leaching in alkaline environments.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coated glass container exhibits improved resistance and stability across a wide pH range, reduced leaching of alkali ions, and enhanced adhesion properties, making it suitable for storing pharmaceutical compositions sensitive to high pH values.
Implementation Method 1
generating plasma through irradiation
Implementation Method 2
a coating process on at least part of the glass surface, comprising: a) surrounding the at least part of the glass surface of the glass element with a precursor P1; and b) irradiating the precursor P1 to generate a plasma
Data Source
AI summary
A coated glass container includes: a glass surface; and a coating that coats at least part of the glass surface to form a coated glass surface. The coating includes at least one layer. The coated glass container fulfills the following parameter: leaching of [Na] ions after an alkaline treatment is 10 mg/l or less [Na] ions.