Coated Solid Supports for Dried Blood Spot Recovery
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Solution Overview
Problem
Current methods for storing and analyzing biological materials, such as biopharmaceutical drugs, face challenges with stability and integrity in blood samples, leading to time-consuming procedures and limitations in throughput due to the need for plasma or whole blood, which also increases animal usage and costs.
Innovation Solution
Development of solid supports, specifically coated papers and membranes, that enhance the recovery of biological materials by using chemicals like vinyl polymers, non-ionic synthetic polymers, and proteins, allowing for stable storage and efficient extraction of biopharmaceutical drugs from dried blood spots.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If plasma or whole blood is used for storing and analyzing biopharmaceutical drugs, then the stability and integrity of biological materials are maintained, but the procedures become time-consuming and animal usage increases
Solution Approach 1:
The patent changes the physical state parameter of blood samples from liquid (plasma/whole blood) to solid (dried blood spots on coated supports). This phase change enables stable storage and analysis while reducing processing time and animal usage, directly resolving the contradiction between reliability and time consumption
Solution Approach 2:
The patent employs disposable solid support cards with dried blood spots instead of requiring continuous use of liquid blood samples. These single-use supports eliminate the need for complex storage and handling procedures, reducing both time and resource requirements while maintaining sample integrity
2Reliability
If plasma or whole blood is used for storing and analyzing biopharmaceutical drugs, then the stability and integrity of biological materials are maintained, but the throughput is limited and costs increase
Solution Approach 1:
By transforming blood samples into dried spots on solid supports, the patent enables high-throughput processing and storage. The solid format allows for easier handling, stacking, and automated processing, directly increasing productivity while maintaining sample stability
Solution Approach 2:
The patent uses porous solid support materials with specific surface properties that facilitate efficient drying and stable storage of dried blood spots. The porous structure allows rapid moisture removal and provides a stable matrix for preserving biopharmaceutical drugs, enabling high-throughput operations
3Measurement precision
If multiple animal bleeds are performed to increase data quality, then the data quality improves, but the number of animals used increases and costs increase
Solution Approach 1:
The patent performs preliminary stabilization by drying blood spots on coated supports immediately after collection. This preliminary action preserves the biological material in a stable state, allowing multiple analyses from the same sample without requiring additional animal bleeds, thus improving data quality while reducing animal usage
Solution Approach 2:
The transformation to solid dried blood spots on coated supports enables repeated extraction and analysis of the same sample. This parameter change from liquid to solid state allows multiple measurements from a single animal sample, improving measurement precision without increasing the quantity of animals needed
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of coated solid supports significantly improves the recovery of biopharmaceutical drugs, reducing the need for multiple animal bleeds and increasing data quality, while enabling efficient processing and analysis, thus addressing the limitations of existing methods.
Implementation Method 1
at least one surface coated with a chemical that enhances the recovery of a biological material from said surface
Implementation Method 2
absorbent material such as Whatman 903 Neonatal STD paper
Data Source
AI summary
The present invention relates to solid supports that are used for the storage and further processing of biological materials. The invention is particularly concerned with solid supports which have at least one surface coated with a chemical that enhances the recovery of the biological material from the support. Methods of preparing and using the solid supports are also described.