Biodegradable-Coated Supraparticles for Burst Release Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing mesoporous silica supraparticles exhibit high initial payload release (burst release) leading to higher dosing frequency and potential toxicity, limiting sustained release and efficacy.
Innovation Solution
Coating supraparticles with a biodegradable coating, such as fibrin or chitosan, to control payload release and reduce initial burst release, even when loaded with high levels of payload.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If supraparticles are loaded with high levels of payload, then the therapeutic efficacy is improved, but the initial burst release increases causing toxicity and requiring higher dosing frequency
Solution Approach 1:
A biodegradable coating layer is introduced as an intermediary between the supraparticle core and the external environment. This coating acts as a barrier that controls the release of payload, preventing the harmful burst release effect while allowing controlled, sustained release over time. The coating material serves as a mediator that modifies the interaction between the high payload load and the biological system.
Solution Approach 2:
The patent changes the physical and chemical parameters of the supraparticle surface by applying a biodegradable coating. This modification alters the release kinetics parameters, transforming the release profile from a harmful burst pattern to a controlled sustained release pattern. The coating changes the surface properties and mass transfer characteristics of the supraparticle.
2Quantity of substance
If supraparticles are loaded with high levels of payload, then the therapeutic efficacy is improved, but the dosing frequency increases due to burst release
Solution Approach 1:
The biodegradable coating serves as a temporal mediator that extends the release duration. By introducing this intermediate layer, the high payload loading is released gradually over an extended period rather than in an immediate burst, thereby reducing dosing frequency while maintaining therapeutic efficacy.
Solution Approach 2:
The biodegradable coating enables continuous, sustained release of the payload over an extended time period. This continuous action replaces the intermittent dosing required by burst release formulations, maintaining therapeutic levels of the drug in the body over time without requiring frequent administration.
3Quantity of substance
If supraparticles are loaded with high levels of payload, then the therapeutic efficacy is improved, but the potential side effects from initial release increase
Solution Approach 1:
The biodegradable coating acts as a protective intermediary layer that prevents direct contact between the high concentration of payload and the biological system during the initial phase. This intermediate barrier filters and controls the release, preventing toxic burst effects while allowing gradual, safe release of the therapeutic agent.
Solution Approach 2:
The biodegradable coating is applied in advance to prevent the harmful burst release effect before it can occur. This preliminary protective measure counteracts the potential toxicity by creating a release barrier that prevents rapid payload discharge, thereby preventing rather than treating the harmful effect.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biodegradable coating significantly reduces initial burst release, enabling sustained and controlled payload release profiles, improving therapeutic efficacy and safety.
Implementation Method 1
coating supraparticles with a biodegradable coating can drastically reduce the initial burst release of a payload
Implementation Method 2
controlled payload release profiles
Data Source
AI summary
The present disclosure relates to supraparticles loaded with high levels of payload and having controlled payload release profiles. In particular, supraparticles made of mesoporous silica nanoparticles and elecrosprayed with alginic acid which is then coated or formulated with biodegradable materials is disclosed. Such supraparticles may be used in a range of therapeutic applications.