Coating agent based on a copper-nanoparticle biohybrid and use thereof as a biocidal agent

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Solution Overview

Problem

Current materials and masks lack effective biocidal properties against SARS-CoV-2, particularly in terms of long-lasting protection and versatility for various surfaces, and existing copper-based antimicrobial agents are not effectively used as coating agents.

Innovation Solution

A hybrid material comprising a protein matrix and monodisperse copper nanoparticles (Cu3(PO4)2, Cu2O, or Cu(0)) is developed, which can be applied as a coating on surfaces like masks, metals, and paper, providing stable and reusable biocidal activity against SARS-CoV-2 and other pathogens.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If standard masks and surfaces are used, then basic protection is provided, but biocidal activity against SARS-CoV-2 is insufficient and not long-lasting

Engineering Contradiction:
Improvebiocidal activityVSAvoidlong-lasting protection
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies composite materials by combining copper nanoparticles with a protein matrix (such as gelatin or albumin) to create a hybrid coating material. This composite structure provides both the biocidal properties of copper and the stabilizing, adhesion-enhancing characteristics of the protein matrix, resulting in a coating that maintains effective biocidal activity against SARS-CoV-2 over extended periods while adhering well to various surfaces.

Inventive Principle:
Principle #40Composite materials

2Object-affected harmful factors

If copper-based antimicrobial agents are used, then antibacterial effects are achieved, but biocidal capacity as a coating agent is not demonstrated

Engineering Contradiction:
Improveantimicrobial effectVSAvoidcoating agent application
Core Design Contradiction:
Object-affected harmful factorsVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by controlling the size of copper particles to the nanoscale (1-100 nm) and adjusting their concentration within the protein matrix coating. This size reduction and concentration optimization enhance the biocidal effectiveness against both bacteria and viruses including SARS-CoV-2, while the protein matrix provides the necessary adhesion and stability for coating applications on various surfaces.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If masks are made with additional protective materials, then protection efficiency increases, but mask complexity and potential discomfort increase

Engineering Contradiction:
Improveprotection efficiencyVSAvoidmask structure
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies universality by creating a multi-functional coating that simultaneously provides viral inactivation, bacterial protection, and surface adhesion. The copper-protein hybrid coating can be applied to various mask materials (polypropylene, cotton, surgical fabrics) and surfaces, providing broad-spectrum biocidal activity without requiring complex structural modifications to the base mask design.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The hybrid material significantly increases protection against SARS-CoV-2 by maintaining biocidal activity through multiple wash cycles and high temperatures, demonstrating enhanced efficacy compared to standard masks and surfaces, with the ability to be reused and applied on diverse materials.

Implementation Method 1

nanomaterials with biocidal activity can be used as coating additives on surfaces of a different nature, exhibiting a high versatility

Methodology Applied
Scientific EffectBiocidal activity:

Implementation Method 2

The adhesion of the coating has been highly efficient and stable through washing cycles of the same and exposed to high temperatures

Methodology Applied
Scientific EffectAdhesion: Adhesive

Data Source

PatentUS20240180162A1Coating agent based on a copper-nanoparticle biohybrid and use thereof as a biocidal agent
Publication Date: 2024.06.06 CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
  • US20240180162A1 patent drawing
  • US20240180162A1 patent drawing
  • US20240180162A1 patent drawing

AI summary

A hybrid material includes a protein matrix and nanoparticles (NPs) of a type of Cu; a preparation method thereof; and the uses thereof. The hybrid material displays activity that inhibits SARS-CoV-2 proteins, which makes it usable as a biocidal agent and as an agent for coating and disinfecting materials selected from metal, paper, textiles and approved surgical face masks.