Coating Deposition Rate Control for Medical Device Drug Release

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Solution Overview

Problem

Current methods for controlling active agent release from coatings on medical devices lack the ability to precisely regulate the release rate, leading to potential over- or under-dosing due to variations in elution rates, which can result in harmful side effects or inadequate therapeutic effects.

Innovation Solution

The method involves adjusting the deposition rate of the coating material to predetermine the release kinetics of active agents, allowing for accelerated or decelerated release by controlling the structural configuration of the coating, thereby achieving a pre-selected elution rate.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the active agent is provided in a coating system on a medical device, then the active agent can be delivered to a specific target tissue to maximize therapeutic effect and limit side effects, but the release rate cannot be precisely controlled leading to potential over- or under-dosing

Engineering Contradiction:

Improvetherapeutic effect reliabilityVSAvoidrelease rate control precision

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by varying the deposition rate of the coating material to control the release kinetics of the active agent. By adjusting parameters such as deposition rate, coating thickness, and material composition, the invention achieves precise control over the release rate, resolving the contradiction between reliable therapeutic effect and precise release rate control.

Inventive Principle:

Principle #35Parameter changes

2Productivity

If the active agent elutes too quickly, then more active agent is dosed to the target tissue faster, but harmful side effects occur due to over-dosing

Engineering Contradiction:

Improveactive agent delivery speedVSAvoidside effects

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The invention uses parameter changes by adjusting the deposition rate and coating composition to control the elution rate. By optimizing these parameters, the coating achieves controlled release that prevents both too-fast delivery (which causes side effects) and too-slow delivery (which reduces therapeutic effectiveness).

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent implements dynamics by creating a coating system where the release rate can be adjusted and optimized. The coating material and deposition parameters are designed to provide dynamic control over the release kinetics, allowing the system to adapt to different therapeutic requirements while preventing harmful side effects from over-dosing.

Inventive Principle:

Principle #15Dynamics

3Object-affected harmful factors

If the active agent elutes too slowly, then fewer side effects occur, but therapeutic effect is inadequate due to under-dosing

Engineering Contradiction:

Improveside effectsVSAvoidtherapeutic effect

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The invention applies parameter changes by optimizing the deposition rate and coating composition to achieve the desired release rate. This ensures that the active agent is released at a controlled pace that provides sufficient therapeutic effect while minimizing side effects, thereby resolving the contradiction between harm reduction and therapeutic reliability.

Inventive Principle:

Principle #35Parameter changes

4Adaptability or versatility

If the coating is applied at different deposition rates, then different elution rates are achieved, but the process complexity increases

Engineering Contradiction:

Improveelution rate variabilityVSAvoidcoating process complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent uses parameter changes as a straightforward approach to achieve different elution rates by adjusting the deposition rate and coating composition. This method provides adaptability and versatility in controlling release characteristics while maintaining relatively simple coating processes, avoiding excessive complexity.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables precise control over the release of active agents, ensuring optimal therapeutic effects while minimizing side effects by manipulating the deposition rate to achieve desired release profiles.

Implementation Method 1

applying the coating composition to the medical device at the selected deposition rate

Methodology Applied

Scientific EffectDeposition: Deposition (physical)

Data Source

PatentUS7709049B2Methods, devices, and coatings for controlled active agent release

Publication Date: 2010.05.04 SURMODICS COATINGS LLC

AI summary

The present invention relates to methods, devices, and coatings, wherein active agent release is determined by deposition rate of a coating or material. In an embodiment, the invention includes a method for coating a medical device, including identifying active agent elution rates for a coating composition applied to substrates at a plurality of coating deposition rates, selecting one of the coating deposition rates, and applying the coating composition to the medical device at the selected deposition rate. In an embodiment, the invention includes a combination including a medical device and a composition for coating the surface of a medical device with an active agent in a manner that permits the coated surface to release the active agent over time when implanted in vivo.