Coaxial Dual-Fluid Injection Head for Low-Trauma Cell Delivery
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Solution Overview
Problem
Existing methods for injecting substances into tissue using large-diameter cannulas result in insufficient positioning, tissue perforation, significant trauma, and loss of substance, leading to reduced treatment efficacy and unwanted substance accumulation outside the target area.
Innovation Solution
A dual-fluid injection system with a first conduit for creating a channel using a working fluid and a second conduit for delivering active ingredients, utilizing preacceleration and reacceleration zones to minimize shear stress and ensure precise delivery of cells or substances into tissue without needles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a large-diameter injection cannula (up to 1.6 mm) is used for manual substance injection, then the cannula can deliver a sufficient volume of substance, but tissue trauma and perforation risk increase significantly
Solution Approach 1:
The injection process is segmented into two distinct phases using separate conduits: a first conduit delivers a working fluid to create a tissue channel, and a second conduit delivers the active ingredient through the pre-created channel. This segmentation allows each conduit to have optimized, smaller diameters that reduce tissue trauma while maintaining effective substance delivery volume.
Solution Approach 2:
The working fluid acts as an intermediary that first creates a tissue channel, which then serves as a pathway for the active ingredient. This intermediary approach allows the active ingredient to be delivered through a smaller, less traumatic conduit since the channel creation function is separated to the first conduit.
2Quantity of substance
If a large-diameter cannula is used for substance injection, then sufficient substance volume can be delivered, but substance loss outside the target area increases
Solution Approach 1:
By separating the channel creation function (first conduit) from the active ingredient delivery function (second conduit), the system enables precise delivery of the active ingredient through a smaller conduit that fits better within the tissue channel, reducing substance leakage and accumulation outside the target area.
3Quantity of substance
If multiple punctures are performed with one needle per puncture to treat a circumferential circular area, then complete coverage is achieved, but treatment time increases and muscle damage accumulates
Solution Approach 1:
The instrument segments the treatment function into two simultaneous processes through two conduits: channel creation and active ingredient delivery. This allows a single puncture location to deliver both functions, enabling circumferential treatment through fewer punctures and reducing overall treatment time and cumulative muscle damage.
Solution Approach 2:
The system merges the channel creation and active ingredient delivery functions into a single integrated instrument with two conduits, allowing both functions to be performed simultaneously at each puncture location, thereby reducing the number of separate punctures needed for circumferential treatment.
4Quantity of substance
If multiple punctures are performed to deliver sufficient substance volume, then complete treatment coverage is achieved, but the regeneration effect of the therapy is reduced
Solution Approach 1:
By separating channel creation from active ingredient delivery into two conduits, the system reduces the number of punctures needed, thereby minimizing cumulative muscle damage and preserving the tissue's natural regeneration effect while still delivering sufficient substance volume through the optimized two-stage process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves precise, needleless delivery of active ingredients with reduced tissue trauma and improved survival rates of cells by minimizing shear stress and ensuring uniform distribution, thereby enhancing treatment efficacy.
Implementation Method 1
a first conduit (11) for output of a first fluid (16) from a first opening (12) of the first conduit (11) in an axial direction (A) in a reacceleration zone (19). In addition, the instrument (10) comprises a second conduit (14) for channeling a second fluid (17) in the reacceleration zone (19) in the axial direction (A) such that at least portions of the second fluid (17) as a result of the flowing of the first fluid (16) in the reacceleration zone (19) are reaccelerated in the axial direction (A) by the first fluid (16) entering the reacceleration zone (19)
Data Source
AI summary
An instrument with a first conduit for emitting a first fluid from a first opening of the first conduit in an axial direction into a reacceleration zone and with a second conduit for channeling of a second fluid in the reacceleration zone in the axial direction is provided such that active ingredient components, e.g. cells, of the second fluid are reaccelerated in the axial direction as a result of a flow in the reacceleration zone by means of the first fluid that enters the reacceleration zone. A coaxial configuration of the first and the second conduit is preferred, because in doing so, around the first opening a shell jet of the second fluid can be created that flows downstream in the axial direction around a central working jet. In addition, a head for an inventive instrument and an application system with an inventive instrument is provided.