American Cockroach Extract Preparation for Bioactive Preservation
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Solution Overview
Problem
The preservation of fresh Periplaneta americana L. bodies is challenging due to rapid rotting and deterioration, which degrades bioactive substances, and existing drying methods waste energy and resources while reducing these substances further.
Innovation Solution
A method involving soaking fresh Periplaneta americana L. in ethanol at specific concentrations and temperatures for extended periods, followed by reflux extraction and concentration, with optional use of clarifying agents and preservatives to maintain bioactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fresh Periplaneta americana L. bodies are preserved by freeze-drying or heating drying, then preservation is achieved, but energy and resources are wasted and bioactive substances are destroyed
Solution Approach 1:
The patent changes the preservation parameter from high-energy freeze-drying/heating to low-energy ethanol soaking at controlled temperatures (4-25°C), maintaining preservation effectiveness while dramatically reducing energy consumption and bioactive substance destruction
Solution Approach 2:
Ethanol is introduced as an intermediary substance that enables preservation without requiring extreme temperatures. The ethanol solution acts as a medium that penetrates the insect bodies, preventing rotting and deterioration while allowing preservation at ambient or refrigerated temperatures
2Reliability
If fresh Periplaneta americana L. bodies are preserved by freeze-drying or heating drying, then preservation is achieved, but bioactive substances are destroyed
Solution Approach 1:
The patent changes the preservation parameter from high-temperature/heating processes to low-temperature ethanol soaking (4-25°C), preventing the thermal destruction of bioactive substances while achieving effective preservation against rotting and deterioration
Solution Approach 2:
Ethanol serves as a protective intermediary that prevents microbial degradation and chemical deterioration of bioactive substances without requiring thermal processing that would destroy these sensitive compounds
3Quantity of substance
If ethanol soaking is performed for extended periods, then bioactive substances are enhanced, but processing time increases
Solution Approach 1:
The patent employs periodic action by specifying optimized soaking durations (10-60 days for initial soaking, then 1-3 days for reflux extraction) that achieve maximum bioactive substance enhancement without unnecessary time extension, balancing extraction efficiency with processing time
Solution Approach 2:
The patent optimizes the soaking time parameter within specific ranges (10-60 days) based on ethanol concentration and temperature conditions, achieving the best balance between bioactive substance enhancement and processing time efficiency
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively preserves the fresh bodies for extended periods, enhances bioactive substances, and reduces energy and resource consumption, resulting in a more potent extract with improved anti-inflammatory activity.
Implementation Method 1
soaking fresh Periplaneta americana L. in ethanol; reflux extracting by ethanol, and then filtering and combining obtained filtrates
Data Source
AI summary
The present application relates to the technical field of medicine, and in particular to Periplaneta americana L. extract, a preparation thereof, a preparation method and application thereof. The method for preparing Periplaneta americana L. extract includes the steps: 1) soaking fresh Periplaneta americana L. extract with ethanol; 2) reflux extracting with ethanol, and then filtering and combining the filtrates; and 3) concentrating the filtrate into extractum. The method uses environmental protection reagents such as ethanol, increases the content of bioactive substances of Periplaneta americana L. extract, saves time, human and material resources, saves energy and reduces production cost. The Periplaneta americana L. extract obtained by the present method has better anti-inflammatory activity and higher content of amino acids.