Cocoon-Based Vascular Patch for Biocompatible Stenosis Prevention

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Solution Overview

Problem

Conventional vascular patches made of synthetic polymers are not biocompatible, leading to complications such as thrombotic angiostenosis, vascular calcification, inflammation, and tissue necrosis, and are expensive, limiting their application to thin blood vessels in the oral and maxillofacial region.

Innovation Solution

A cocoon-based vascular patch is developed by dividing a cocoon into fragments and delaminating them into thinner layers, which are then sterilized and used to promote endothelial cell growth without causing foreign body reactions, thus maintaining vessel diameter and preventing stenosis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional synthetic polymer vascular patches (PET, ePTFE, Gore-Tex) are used, then vascular patch treatment shows better results than direct closure, but they cause thrombotic angiostenosis, vascular calcification, inflammation, and tissue necrosis due to poor biocompatibility

Engineering Contradiction:

Improvevascular function maintenanceVSAvoidthrombotic angiostenosis, vascular calcification, inflammation, tissue necrosis

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the material parameter from synthetic polymer to natural cocoon material, fundamentally altering the biocompatibility characteristics. This parameter change resolves the contradiction by maintaining vascular function while eliminating the harmful thrombotic and inflammatory responses associated with synthetic materials

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses cocoon material which is a natural composite structure consisting of multiple layers with different properties. This composite structure provides both the mechanical strength needed for vascular support and the biocompatibility required to prevent thrombosis and inflammation

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional synthetic polymer vascular patches are used, then vascular patch treatment is effective, but they are expensive and limitedly applied to relatively thin blood vessels

Engineering Contradiction:

Improvevascular patch effectivenessVSAvoidmanufacturing cost and accessibility

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent employs cocoon material which is naturally abundant, inexpensive, and biodegradable. This replaces expensive synthetic polymers with a cost-effective natural material that eliminates the need for long-term persistence, as the cocoon patch degrades and is replaced by native tissue

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The cocoon material provides self-service through its natural biodegradability and ability to support endothelial cell growth. The patch automatically degrades over time while facilitating tissue regeneration, eliminating the need for surgical removal and reducing long-term complications

Inventive Principle:

Principle #25Self-service

3Ease of operation

If direct closure of severely injured blood vessels is performed, then treatment is simple, but it induces angiostenosis leading to cerebral infarction or neurological complications

Engineering Contradiction:

Improvetreatment simplicityVSAvoidvascular function and circulation

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The cocoon vascular patch serves as an intermediary material between the damaged vessel ends. It provides a temporary scaffold that maintains vessel patency and supports tissue regeneration, unlike direct closure which creates immediate stenosis. The patch mediates the healing process while preventing complications

Inventive Principle:

Principle #24Intermediary (Mediator)

4Length of stationary object

If vascular patches are made thicker to maintain vessel diameter, then they better maintain vascular morphology, but they may cause more foreign body reactions and inflammation

Engineering Contradiction:

Improvevessel diameter maintenanceVSAvoidforeign body reactions and inflammation

Core Design Contradiction:

Length of stationary objectVSObject-affected harmful factors

Solution Approach 1:

The patent changes the material composition parameter from synthetic to natural cocoon material, which fundamentally alters the immune response. The natural material allows for greater thickness without proportionally increasing foreign body reactions, as it is recognized by the body as non-alien and supports rather than triggers inflammation

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS10576183B2Cocoon-based vascular patch and manufacturing method thereof

Publication Date: 2020.03.03 REPUBLIC OF KOREA (MANAGEMENT RURAL DEV ADMINISTRATION)

AI summary

Disclosed herein are a cocoon-based, vascular patch and a method for manufacturing the same. The cocoon-based, vascular patch is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a predetermined thickness. The cocoon-based vascular patch can be relatively simply manufactured in a more cost efficient manner than conventional vascular patches, and has excellent cell growth potential and biocompatibility.