Coenzyme Q10 Roller Compaction for Dense, Free-Flowing Particles
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Solution Overview
Problem
Existing methods for preparing coenzyme Q10 particles suffer from inefficiencies in terms of productivity and do not adequately address the issues of instability, poor rheology, and low flowability, making it difficult to dose accurately and handle coenzyme Q10 for industrial applications.
Innovation Solution
A process involving roller compaction of coenzyme Q10 at specific temperature (10-16°C), roll speed (18-22 r.p.m.), roll force (20-30 kN/cm), and roll gap (0.9-1.2 mm) to produce compacted, high-density particles with improved flowability and handling properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If roller compaction is performed at higher temperatures (20-25°C) as disclosed in prior art, then coenzyme Q10 achieves adequate flowability, but production capacity is limited and productivity is low
Solution Approach 1:
The invention changes the temperature parameter from the prior art range of 20-25°C to a lower range of 10-16°C, combined with specific roll speed (18-22 r.p.m.) and roll force (20-30 kN/cm) parameters, to achieve both improved flowability and significantly enhanced production capacity
Solution Approach 2:
The invention optimizes the dynamic parameters of the roller compaction process, specifically setting roll speed between 18-22 r.p.m. and roll force between 20-30 kN/cm, to achieve optimal compaction density and flowability simultaneously, resolving the contradiction between operational ease and productivity
2Productivity
If roller compaction is performed at lower temperatures (10-16°C) with higher roll force (20-30 kN/cm), then production capacity increases by 233%, but energy consumption increases
Solution Approach 1:
The invention changes the temperature parameter to a lower range (10-16°C) and optimizes roll force (20-30 kN/cm) to achieve high production capacity. The energy increase is justified by the 233% productivity improvement and is optimized within the specified parameter ranges to minimize unnecessary energy consumption
3Reliability
If coenzyme Q10 is processed without compaction, then chemical integrity and purity are maintained, but flowability and handling properties remain poor
Solution Approach 1:
The invention applies roller compaction at controlled temperatures (10-16°C) and pressures (20-30 kN/cm) that are optimized to improve flowability and handling properties while maintaining the chemical integrity and purity of coenzyme Q10, resolving the contradiction between reliability and operational ease
4Productivity
If roller compaction is performed with larger roll gap (0.9-1.2 mm), then production capacity increases, but particle density decreases
Solution Approach 1:
The invention optimizes the roll gap parameter to a specific range (0.9-1.2 mm) that achieves an optimal balance between production capacity and particle density, allowing both high productivity and adequate compaction density to be achieved simultaneously
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process significantly enhances production capacity by 233% while maintaining chemical integrity and purity, resulting in compacted coenzyme Q10 with excellent flowability, higher density, and improved compressibility, suitable for pharmaceutical and cosmetic compositions.
Implementation Method 1
roller compaction of coenzyme Q10, wherein the temperature is comprised between 10° C. and 16° C., the roll speed is comprised between 18 r.p.m. and 22 r.p.m., the roll force per unit of roller length is comprised between 20 kN/cm and 30 kN/cm
Data Source
AI summary
The invention relates to a process for preparing compacted coenzyme Q10 particles of high density and improved flowability comprising roller compaction of coenzyme Q10 at a temperature comprised between 10° C. and 16° C., at a roll speed in the range 18-22 r.p.m., at a linear roll pressure in the range 20-30 kN/cm and with a gap between the rollers of 0.9 mm to 1.2 mm. Said process allows substantially increase the production capacity of highly-flowable compacted coenzyme Q10. The invention also relates to the compacted coenzyme Q10 obtainable with such process and to its use for preparing pharmaceutical compositions. The invention also relates to pharmaceutical compositions comprising the compacted coenzyme Q10, and to their therapeutic and cosmetic use.