Seeded Coenzyme Q10 Form II Crystallization for Stable High-Yield Production
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for producing reduced coenzyme Q10 Form II crystal are inefficient and lack industrial scalability, often requiring long times and low yields, and may not produce the crystal under certain conditions.
Innovation Solution
A method involving the use of reduced coenzyme Q10 Form II crystal as a seed crystal in a specific solvent, within a defined temperature range, and controlled cooling and stirring conditions to achieve high yield and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional crystallization methods are used to obtain reduced coenzyme Q10, then the crystal can be produced, but the production time is long and the recovered amount is small
Solution Approach 1:
The patent applies preliminary action by preparing seed crystals of reduced coenzyme Q10 Form II before the main crystallization process. These pre-prepared seed crystals are then added to the supersaturated solution to initiate and accelerate the crystallization process, thereby reducing the overall production time and improving productivity.
Solution Approach 2:
The patent uses seed crystals as copies or templates to guide the formation of new crystals. By adding small amounts of pre-formed reduced coenzyme Q10 Form II crystals to the solution, the crystallization process is templated, ensuring rapid and efficient formation of the desired crystal form with high recovery.
2Quantity of substance
If conventional crystallization methods are used, then reduced coenzyme Q10 can be obtained, but the yield is low and the method lacks industrial scalability
Solution Approach 1:
The patent applies parameter changes by optimizing the crystallization temperature range (32-43°C) and using specific solvents (alcohols, hydrocarbons, esters, or nitrogen compounds). These parameter optimizations ensure high yield of reduced coenzyme Q10 Form II crystals while maintaining ease of manufacture and industrial scalability.
Solution Approach 2:
The patent prepares supersaturated solutions beforehand by dissolving reduced coenzyme Q10 in the selected solvent at elevated temperatures, then cooling to the crystallization range. This preliminary preparation ensures that when seed crystals are added, immediate and high-yield crystallization occurs, making the process suitable for industrial scale-up.
3Productivity
If reduced coenzyme Q10 Form II crystal is used as seed crystal, then the yield improves, but the method requires specific temperature control and solvent selection
Solution Approach 1:
The patent defines specific parameter ranges to balance yield improvement with manageable process control: temperature between 32-43°C, seed crystal amount at 0.5-20% by weight, and specific solvent types. These parameters are optimized to achieve high yield while maintaining ease of control in industrial settings.
4Stability of the object's composition
If existing crystallization methods are used, then reduced coenzyme Q10 can be produced, but the stability and physical properties are inferior
Solution Approach 1:
The patent uses seed crystals of reduced coenzyme Q10 Form II as templates to ensure that all newly formed crystals replicate the stable Form II structure. This templating approach guarantees consistent crystal form, high stability, and excellent physical properties, resolving the issue of inferior stability associated with conventional methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables the efficient production of a stable reduced coenzyme Q10 Form II crystal suitable for industrial scale, with improved reproducibility and purity.
Implementation Method 1
adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32°C to 43°C, containing at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and reduced coenzyme Q10, to prepare a mixture
Implementation Method 2
adding a reduced coenzyme Q10 Form II crystal as a seed crystal... to prepare a mixture, and precipitating a reduced coenzyme Q10 Form II crystal in the mixture
Implementation Method 3
precipitating a reduced coenzyme Q10 Form II crystal in the mixture
Data Source
AI summary
Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. The method for producing a reduced coenzyme Q10 Form II crystal provided by the present invention comprises: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32°C to 43°C, containing at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and reduced coenzyme Q10, to prepare a mixture, and precipitating a reduced coenzyme Q10 Form II crystal in the mixture.