Cognitive Supplement Composition with Defined Ingredient Ratios

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Solution Overview

Problem

Current nutritional supplements for cognitive enhancement often contain multiple ingredients with unclear interactions, leading to inconsistent effects, and most have not shown significant benefits in healthy, broad age range populations, with many formulations potentially causing overstimulation and receptor desensitization.

Innovation Solution

A nutritional supplement composition comprising Ginkgo biloba, rhodiola, acetyl-L-carnitine, and huperzine A, formulated to achieve specific therapeutic thresholds, with a ratio of Ginkgo biloba : rhodiola : acetyl-L-carnitine : huperzine A between 690:1700:8000:0.85 to 1030:2600:12000, and optionally including a vitamin B complex, green tea, and guarana extract, designed for oral administration to enhance cognitive function and mood.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If multiple active ingredients are combined in nutritional supplements for cognitive enhancement, then the potential beneficial effects are increased, but the risk of overstimulation and receptor desensitization increases

Engineering Contradiction:

Improvenumber of active ingredientsVSAvoidoverstimulation and receptor desensitization

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by carefully controlling the dosage levels of each active ingredient in the composition. Specifically, the patent specifies precise amounts: huperzine A (0.1-1.0 mg), vinpocetine (5-50 mg), acetyl-L-carnitine (500-5000 mg), and ginkgo biloba (50-500 mg). These parameter adjustments ensure that the ingredients work synergistically without causing overstimulation, resolving the contradiction between using multiple ingredients and avoiding harmful effects.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite nutritional supplement composition that combines multiple active ingredients (huperzine A, vinpocetine, acetyl-L-carnitine, and ginkgo biloba) with specific ratios. This composite approach allows the ingredients to work together synergistically for enhanced cognitive benefits while the defined composition prevents overstimulation, thus resolving the technical contradiction.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If multiple active ingredients are used in cognitive enhancement supplements, then additive or synergistic effects are expected, but the interactions between ingredients become unclear and effects become inconsistent

Engineering Contradiction:

Improvenumber of active ingredientsVSAvoidconsistency of cognitive enhancement effects

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent ensures reliability by defining specific dosage parameters for each ingredient: huperzine A (0.1-1.0 mg), vinpocetine (5-50 mg), acetyl-L-carnitine (500-5000 mg), and ginkgo biloba (50-500 mg). These controlled parameters ensure consistent and reproducible cognitive enhancement effects across different formulations and studies, resolving the inconsistency problem.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent develops a standardized composite formulation containing four specific active ingredients in defined ratios. This standardized composite approach ensures that the synergistic effects are consistent and reproducible, eliminating the variability associated with different multi-ingredient formulations and establishing reliable cognitive enhancement effects.

Inventive Principle:

Principle #40Composite materials

3Reliability

If most existing supplements are tested, then their efficacy in abnormal or low normal populations is demonstrated, but their effectiveness in healthy, broad age range populations remains unproven

Engineering Contradiction:

Improveclinical effect in selected populationsVSAvoideffectiveness across broad age range

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent creates a universal cognitive enhancement composition designed to benefit healthy individuals across a broad age range (18-74 years). The multi-functional formulation addresses multiple cognitive domains (attention, memory, processing speed) simultaneously, making it adaptable and effective for diverse healthy populations rather than being limited to specific pathological groups.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent uses optimized dosage parameters (huperzine A: 0.1-1.0 mg, vinpocetine: 5-50 mg, acetyl-L-carnitine: 500-5000 mg, ginkgo biloba: 50-500 mg) that are effective across different age groups and cognitive baseline levels in healthy individuals, enabling broad applicability while maintaining clinical efficacy.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS10105406B2Compositions and methods for enhancing brain function using acetyl-L-carnitine, huperzine A, Ginkgo biloba, and vitamin B complex

Publication Date: 2018.10.23 KEYVIEW LABS

AI summary

A nutritional supplement composition for enhancing cognitive function includes Ginkgo biloba, rhodiola, acetyl-L-carnitine and huperzine A. The Ginkgo biloba, rhodiola and acetyl-L-carnitine are in a ratio a:b:c respectively such that a as the Ginkgo biloba is between about 690 and 1030, b as the rhodiola is between about 1,700 and 2,600 and c as the acetyl-L-carnitine is between about 8,000 and 12,000. The composition is formulated for oral administration and the Ginkgo biloba, rhodiola, acetyl-L-carnitine and huperzine A together account for at least 80 wt % of a dosage unit of the nutritional supplement composition.