Cohesive Bone Composition for Osseous Defects
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Solution Overview
Problem
Existing bone repair compositions struggle to maintain their shape and effectively promote new bone growth in osseous defects and bone voids, as they often lack the necessary cohesion and osteoinductive properties.
Innovation Solution
A cohesive bone composition is developed, combining a moldable bone composition made from cortical and cancellous bone, mixed with a bone gel composition, which can be molded into desired shapes when subjected to a fluid, incorporating demineralized and mineralized components to enhance bone repair and growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bone particles of various sizes are used to promote new bone growth, then osteoinductive properties are improved, but the composition lacks cohesion and cannot maintain its shape
Solution Approach 1:
The patent combines multiple bone particle types (cortical bone shavings, cortical bone powder, cancellous bone particles) with specific size distributions and mineralization states to create a composite material that maintains both osteoinductive properties and structural cohesion. The combination of demineralized and mineralized portions provides both biological activity and mechanical stability.
Solution Approach 2:
The patent applies different mineralization states and particle sizes to different portions of the bone composition. Cortical bone shavings provide structural framework, cortical bone powder fills spaces, and cancellous bone particles provide osteoinductive surfaces. This local differentiation allows each component to fulfill its specific function while maintaining overall cohesion.
2Ease of operation
If the bone composition is made moldable by adding gelatinous materials, then ease of shaping is improved, but the composition may lack the necessary structural integrity for bone repair
Solution Approach 1:
The patent utilizes the mineralization state of bone particles as a key parameter to control the balance between moldability and structural integrity. Demineralized portions provide flexibility and moldability, while mineralized portions provide structural strength and stability. This parameter differentiation allows the composition to be both shapeable and structurally sound.
Solution Approach 2:
The patent segments the bone composition into distinct mineralized and demineralized portions, each serving different functions. The mineralized portions maintain structural integrity while the demineralized portions enable moldability. This segmentation allows the composition to exhibit both moldable and structurally sound characteristics simultaneously.
3Reliability
If the bone composition uses specific particle size distributions, then bone growth promotion is improved, but the manufacturing complexity increases
Solution Approach 1:
The patent segments the bone processing into distinct stages: cortical bone processing (shaving, powdering), cancellous bone processing (particle formation), and mineralization control. Each segment can be manufactured separately using standard techniques, reducing overall manufacturing complexity while achieving the desired particle size distribution for optimal bone growth.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cohesive bone composition effectively maintains its shape and promotes new bone growth by providing a moldable and osteoinductive matrix that can be easily shaped and applied to bone defects, enhancing the repair process.
Implementation Method 1
The use of particles of various specific sizes and distributions have been determined to have beneficial characteristics for new bone growth in the treatment of osseous defects and bone voids
Implementation Method 2
The portions are free-dried and mixed together to form a freeze-dried moldable bone composition
Implementation Method 3
the mixture is autoclaved under heat and pressure to form a gelatin
Data Source
AI summary
A cohesive bone composition is made from a moldable bone composition intermixed with a bone gel composition. The cohesive bone composition is made from human cadaver bone. A fluid can be added, the fluid may also be laden with cells.