Coil Occluder for Venous Arterialization in Diffuse CAD
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Solution Overview
Problem
Conventional revascularization techniques, such as CABG and PTCA, are ineffective for patients with diffuse CAD and refractory angina, and pose challenges for diabetic patients with advanced coronary atherosclerosis, leading to high mortality and morbidity rates, especially in cases where vasculature is unsuitable for grafting.
Innovation Solution
The development of an occluder device and occluder system comprising a coil with expandable configurations for arterialization of veins, allowing for selective autoretroperfusion to provide oxygenated blood to ischemic areas, facilitating grafting and improving blood flow in diffusely diseased vessels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional revascularization techniques (CABG or PTCA) are used, then revascularization can be achieved in suitable patients, but the techniques are ineffective for patients with diffuse CAD and refractory angina
Solution Approach 1:
The invention segments the revascularization approach by creating separate pathways: conventional forward flow revascularization for suitable patients and retrograde revascularization through venous collaterals for diffuse CAD patients. This segmentation allows each technique to be optimized for its specific indication, resolving the contradiction between effectiveness and adaptability.
Solution Approach 2:
The invention inverts the traditional revascularization direction by delivering blood flow retrograde through venous vessels and collaterals from distal to proximal, rather than the conventional antegrade approach. This inversion enables treatment of diffuse CAD where forward flow techniques fail, expanding adaptability while maintaining effectiveness.
2Reliability
If arterialization of venous vessels is performed, then continuous oxygen-rich blood supply to ischemic tissues is achieved, but stress on venous vessels increases which may cause rupture
Solution Approach 1:
The invention applies preliminary action by performing gradual arterialization of venous vessels through controlled delivery of antegrade blood flow before full retrograde flow is established. This gradual process allows venous vessels to adapt to increased pressure stresses, preventing rupture while achieving continuous oxygen-rich blood supply.
Solution Approach 2:
The invention provides beforehand cushioning by using the venous system's natural compliance and capacity to absorb pressure fluctuations as a buffer during the transition to arterialization. This cushioning effect protects against sudden pressure spikes that could cause venous rupture while maintaining reliable blood supply.
3Ease of operation
If coil occlusion devices are used for arterialization, then selective occlusion of luminal organs is achieved, but device complexity increases
Solution Approach 1:
The invention uses the venous system itself as an intermediary pathway, eliminating the need for complex arterial access and navigation equipment. By delivering occlusion devices through venous collaterals, the system simplifies the overall procedure while maintaining selective occlusion capability, as the venous pathway is more accessible and less complex than arterial routes.
Data Source
AI summary
Coil occluder devices and systems and methods of using the same. In an exemplary embodiment of an occluder system of the present disclosure, the occluder system comprises an occluder device comprising a coil having at least a first, uncompressed configuration and a second, compressed configuration, wherein the coil in the first, uncompressed configuration is configured to fit within a delivery mechanism sized and shaped to fit within a mammalian luminal organ, and wherein the coil in the second, compressed configuration is configured to occlude a mammalian luminal organ, and a delivery mechanism sized and shaped to fit within the mammalian luminal organ, the delivery mechanism configured to receive the coil in the first, uncompressed configuration within a lumen defined within the delivery mechanism.