Cold Extrusion Veterinary Chews Preserving Active Ingredients
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Solution Overview
Problem
Current veterinary oral medication forms for animals face challenges due to poor palatability, leading to refusal by pets and increased treatment costs, and existing methods for stabilizing active ingredients during extrusion and storage are ineffective, resulting in significant losses and reduced efficacy.
Innovation Solution
A highly palatable ductile chewable veterinary composition produced by cold extrusion, incorporating partially gelatinized starch, meat flavoring, and a softener, which maintains the stability and bioavailability of active ingredients, allowing for effective control of both internal and external parasites and diseases without the need for high temperatures or pressures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional extrusion processes are used to produce oral veterinary medication, then production efficiency is improved, but active ingredient stability deteriorates due to high temperatures and pressures
Solution Approach 1:
The patent changes the extrusion parameters from conventional high temperature and pressure to low temperature (below 40°C) and low pressure conditions. This parameter change allows the extrusion process to proceed efficiently while preserving the stability of active ingredients that would otherwise be degraded by conventional extrusion conditions.
Solution Approach 2:
The patent uses a composite matrix system comprising starch, protein, and lipid components that work together to protect active ingredients during extrusion. This composite material structure provides a protective environment that maintains ingredient stability while allowing the extrusion process to occur under gentler conditions.
2Speed
If high temperatures and pressures are applied during extrusion, then production speed is improved, but active ingredient loss increases
Solution Approach 1:
The patent modifies the extrusion parameters to operate at temperatures below 40°C and reduced pressure levels. This parameter optimization maintains adequate production speed while preventing thermal and mechanical degradation of active ingredients, thereby reducing substance loss.
3Ease of operation
If conventional coating methods are used to mask unpleasant tastes, then palatability is improved, but manufacturing complexity increases
Solution Approach 1:
The patent combines multiple functions into the extrusion process itself. The same extrusion process that forms the dosage form also incorporates flavoring agents and creates the final palatable product structure, eliminating the need for separate coating operations and reducing manufacturing complexity.
4Reliability
If forced administration methods are used, then treatment efficacy is improved, but animal stress and handling difficulty increase
Solution Approach 1:
The patent changes the sensory parameters of the medication through careful selection of flavoring agents and matrix components that create palatable textures and tastes. This parameter optimization transforms the administration experience from stressful forced feeding to voluntary consumption, improving ease of operation while maintaining treatment efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition is stable, palatable, and bioavailable, achieving high efficacy in treating a wide range of parasites and diseases, with minimal active ingredient loss during production and storage, and can be administered easily by animal keepers without the need for veterinary intervention.
Implementation Method 1
partially gelatinized starch
Implementation Method 2
partially gelatinized starch
Implementation Method 3
a softener
Implementation Method 4
The composition is produced by cold extrusion
Data Source
AI summary
The present invention is directed to palatable ductile chewable veterinary composition for oral administration. The composition is capable of killing endo-parasites and ecto-parasites and/or can be used for treating prophylactic or curative animal diseases, and it is useful for the treatment of any warm-blooded non-human animal, including herd animals, like horses, cattle, sheep or poultry and preferably pets like dogs and cats. It consists basically of (A) an effective amount of one or more ingredients that are active against animal pests, pathogens or animal diseases; (B) meat flavoring; (C) partially gelatinized starch; (D) a softener; and (E) up to 9% water.