Cold Plasma Jet for Sarcoma Cell Removal
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Solution Overview
Problem
Current treatments for soft tissue sarcoma, such as radiation and surgery, may leave behind microscopic tumor cells, and conventional laser surgery causes thermal damage, while the effectiveness of cold atmospheric plasma (CAP) in selectively killing cancer cells is not fully understood, particularly regarding the role of p53 gene expression and cell proliferation rates.
Innovation Solution
Developing a method to determine optimal time and power settings for CAP treatment of soft tissue sarcomas by testing various settings on different cell lines, generating a database for predicting effective settings, and integrating this data into an electrosurgical system for precise CAP application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional laser surgery is used to remove tumor cells, then cell removal is achieved, but thermal damage and necrosis occur
Solution Approach 1:
The patent replaces thermal-based laser surgery with a non-thermal plasma-based system. The cold atmospheric plasma jet delivers reactive species and energy to cancer cells through chemical and physical interactions rather than thermal heating, thereby achieving cell removal without the thermal damage and necrosis associated with conventional laser surgery
Solution Approach 2:
The invention changes the fundamental parameter of temperature by using 'cold' atmospheric plasma with ion temperatures close to room temperature. This parameter change allows the system to interact with tissue chemically rather than thermally, eliminating thermal damage while maintaining effective cell removal capability
2Ease of manufacture
If complete surgical excision is performed to remove all tumor cells, then macroscopic tumor removal is achieved, but microscopic residual cells remain
Solution Approach 1:
The cold atmospheric plasma jet provides localized treatment to the surgical margin and residual tumor cells. The plasma can be precisely directed and controlled to treat specific areas where microscopic cells may remain, applying the right amount of energy and reactive species locally without affecting surrounding healthy tissue
Solution Approach 2:
The plasma treatment can be applied as an adjuvant therapy before or after surgical excision to eliminate residual microscopic cells. By treating the surgical field preliminarily or post-operatively, the system addresses potential residual cells that would otherwise be missed by conventional excision alone
3Adaptability or versatility
If cold atmospheric plasma is applied to achieve selective cancer cell death, then specific cell removal is possible, but optimal treatment settings are not well understood
Solution Approach 1:
The system incorporates dynamic control of plasma treatment parameters including power settings, gas flow rates, and treatment duration. These parameters can be adjusted in real-time based on the specific cancer cell line being treated, allowing optimization of selective cell death while adapting to different tissue types and treatment requirements
Solution Approach 2:
The invention includes mechanisms for monitoring treatment effectiveness and adjusting parameters accordingly. By establishing relationships between plasma parameters and cell line sensitivity, the system can provide feedback-based optimization to achieve selective cancer cell death while minimizing treatment complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method effectively reduces sarcoma cell viability in a time- and power-dependent manner, providing a minimally invasive treatment option that can be tailored to specific cancer types, potentially improving treatment outcomes by selectively targeting cancer cells without causing thermal damage.
Implementation Method 1
Cold non-thermal atmospheric plasmas can have tremendous applications in biomedical technology. In particular, plasma treatment can potentially offer a minimum-invasive surgery that allows specific cell removal without influencing the whole tissue.
Implementation Method 2
non-thermal plasma interaction with tissue may allow specific cell removal without necrosis. In particular, these interactions include cell detachment without affecting cell viability, controllable cell death etc.
Data Source
AI summary
A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with said computing device, settings data associated with said selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with said computing device, said retrieved settings data to a cold atmospheric plasma system.