Cold Tissue Processing Bench for Uniform Sample Cooling
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Solution Overview
Problem
Existing methods for tissue handling in preclinical studies lack standardized cold storage and transportation systems, leading to inconsistent temperature exposure, tissue damage, and compromised analysis results due to inadequate insulation and contamination risks.
Innovation Solution
A cold processing device utilizing a cooler case with an interior division and poly lactic acid (PLA) components for uniform cooling, combined with a tissue cutting bench, spore body, and tissue handling unit, ensuring all tissues and biological samples are exposed to a consistent cold environment during cutting, storage, and transport.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If aluminum foil is wrapped around the cutting bench to provide cold environment, then cold effect is provided, but the foil is torn at each scalpel stroke and edges damage the tissue
Solution Approach 1:
The patent replaces the reusable aluminum foil with a disposable plastic wrap that is torn along a predetermined line after use. This disposable approach eliminates the contamination and damage issues associated with repeatedly tearing and rewrapping aluminum foil, while maintaining the cold environment function throughout the procedure.
Solution Approach 2:
The plastic wrap is designed with a predetermined tear line that segments the wrap into a usable portion and a discarded portion. This segmentation allows for clean, controlled tearing without damaging the tissue or the remaining wrap, solving the problem of foil edges damaging tissue during repeated use.
2Temperature
If aluminum foil is used to wrap the cutting bench, then cold environment is provided, but the foil must be rewrapped each time a new tissue arrives
Solution Approach 1:
The disposable plastic wrap with predetermined tear line eliminates the need to rewrap the cutting bench for each new tissue sample. The wrap remains intact and functional throughout the entire procedure, significantly reducing the time lost to rewrapping operations.
Solution Approach 2:
The plastic wrap maintains continuous cold environment protection throughout the entire tissue processing procedure without interruption. The predetermined tear line allows for clean separation without compromising the cold environment, enabling continuous work without stopping to rewrap.
3Temperature
If ice or batteries are placed in the foam container for cold storage, then cold effect is provided, but the cold cannot be provided to all parts of the tissue equally
Solution Approach 1:
The patent applies different thermal properties to different parts of the storage system. The foam container provides insulation, while the plastic wrap in direct contact with the tissue provides conductive cooling. This local differentiation of thermal properties ensures uniform temperature distribution across all tissue parts.
Solution Approach 2:
The system combines multiple materials with different thermal properties: foam for insulation and plastic wrap for conductive cooling contact. This composite approach creates a unified cooling system that provides equal cold effect to all tissue parts while maintaining insulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device maintains homogeneous temperature distribution, preventing tissue trauma and analysis disruptions, allowing for standardized handling and long-term transport of tissues and biological samples without damage or contamination.
Implementation Method 1
heat conduction is the transfer of heat from a hot region to a colder region in a solid material or stagnant fluid... heat passes from the high temperature zone to the low temperature zone by conduction... heat transfer coefficient of poly lactic acid (PLA) is 0.13 W/m·K
Data Source
AI summary
Disclosed herein is a cold processing device which is developed for the portioning and storage of the tissues of treated animal during animal experiments and for the non-mixing and transportation of the tissues, and for the transportation and protection of blood and similar liquid materials taken from the animal, for helping to ensure standardization in experiments. The disclosure also relates to the prevention of a trauma that may occur on the tissue during transportation or external factors that may change the analysis to be made, with the help of the equal cold effect on every part of the tissue taken from the animal since the inventive cold processing device is for animal experiments in preclinical studies and, is a cold storage and transport system.