Collagen-Binding Peptide Immobilized Bone Graft Scaffolds
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Solution Overview
Problem
Current bone graft materials and scaffolds for tissue engineering face challenges in efficiently promoting bone tissue regeneration, particularly in periodontal tissue repair, due to high costs and thermal instability of collagen-based extracellular matrices, and the need for improved immune reaction safety and prolonged drug effects.
Innovation Solution
Immobilizing peptides that induce type I collagen binding on the surface of bone graft materials and scaffolds, specifically using amino acid sequences from bone sialoprotein with added cysteine at the N-terminal end, to enhance collagen adhesion and calcification, thereby improving tissue regeneration efficiency and reducing immune reaction risks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If collagen is used as extracellular matrix material for bone grafts, then tissue regeneration ability is improved, but cost increases and thermal stability decreases
Solution Approach 1:
The patent extracts the critical functional domain from full-length collagen and uses only the necessary peptide sequence (e.g., GFOGER motif) to achieve collagen-binding function. This extraction eliminates the need for expensive, thermally unstable full collagen while retaining the essential tissue regeneration capability through selective binding to type I collagen in the extracellular matrix.
Solution Approach 2:
The patent creates a simplified copy or mimicry of collagen's functional binding site using synthetic peptides that replicate the key adhesive sequence. These peptide copies bind to integrins and other receptors similarly to full collagen but are cheaper to produce and more thermally stable, thus resolving the contradiction between regeneration ability and manufacturing ease.
2Reliability
If peptides are immobilized on bone graft surface, then collagen binding and bone tissue regeneration are improved, but manufacturing complexity increases
Solution Approach 1:
The patent changes the physical-chemical parameters of the bone graft surface by controlling peptide immobilization conditions such as pH, temperature, and crosslinking density. By optimizing these parameters, the patent achieves effective collagen binding with a relatively simple manufacturing process, avoiding excessive complexity while maintaining high reliability of collagen binding.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The immobilized peptides significantly increase bone tissue regeneration rates by promoting collagen binding and calcification, while minimizing immune reactions and ensuring stable drug effects, thus enhancing the effectiveness of bone graft materials and scaffolds in tissue engineering applications.
Implementation Method 1
peptides specifically binding to type I collagen immobilized on the surface
Implementation Method 2
have peptides specifically binding to type I collagen immobilized on the surface thereof
Data Source
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AI summary
The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.