Collagen-Bioactive Glass Composite Bone Graft for Regeneration

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Solution Overview

Problem

Current bone graft materials face challenges such as donor site morbidity, variable performance, risk of infection, and limited effectiveness in maintaining structural integrity and promoting rapid bone regeneration, particularly in particulate forms like hydroxyapatite and calcium sulfate, which often resorb too quickly or are difficult to maintain in surgical sites.

Innovation Solution

A composition combining extracellular matrix protein collagen with bioactive glass ceramic, which undergoes ion exchange to form hydroxyapatite and release calcium and silicate ions, facilitating osteoblast differentiation and proliferation, and is delivered via a minimally invasive kit system to enhance bone regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If particulate bone graft materials like hydroxyapatite or calcium sulfate are used, then osteoconductive properties are provided, but the materials resorb too quickly or are difficult to maintain in surgical sites

Engineering Contradiction:

Improvemaintenance of structural integrityVSAvoidresorption rate

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent combines collagen fibers with hydroxyapatite particles to create a composite bone graft material. The collagen matrix provides structural integrity and slower resorption, while the hydroxyapatite particles provide osteoconductive properties. This composite structure resolves the contradiction by maintaining structural stability while promoting bone growth.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The bone graft material is formulated with controlled porosity to allow bone ingrowth while maintaining structural integrity. The porous structure provides scaffolding for new bone formation without compromising the overall structural stability, addressing both the need for maintenance and controlled resorption.

Inventive Principle:

Principle #31Porous materials

2Reliability

If autograft bone is used to fill bony defects, then osteoinductive properties are achieved, but donor site morbidity and extended hospital stay occur

Engineering Contradiction:

Improvebone regeneration effectivenessVSAvoiddonor site morbidity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses synthetic bone graft materials that can be discarded after single use, eliminating the need for donor sites. These synthetic materials provide sufficient osteoinductive and osteoconductive properties without the harmful effects of harvesting bone from the patient's own body, such as donor site pain and morbidity.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The synthetic bone graft material acts as an intermediary that provides the necessary growth factors and structural support for bone regeneration without requiring living donor tissue. This mediator approach achieves bone regeneration effectiveness while avoiding the harmful effects of autograft harvesting.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If allograft bone is used as bone graft substitute, then similar outcomes to autograft are achieved, but higher cost and slower incorporation occur

Engineering Contradiction:

Improvebone graft outcomeVSAvoidincorporation rate

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent modifies the physical and chemical parameters of the synthetic bone graft material, including porosity, surface area, and composition ratios, to optimize incorporation rate. By adjusting these parameters, the material achieves faster integration with host bone while maintaining reliable bone graft outcomes, overcoming the slow incorporation rate of traditional allografts.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The collagen-bioactive glass composite provides a scaffold for bone regeneration, promoting rapid tissue repair by stimulating osteoblast activity and maintaining structural integrity, while being cost-effective and easily manufacturable for widespread use in bone regenerative surgery.

Implementation Method 1

the ceramic component undergoes an ion exchange with the surrounding body fluid to form hydroxyapatite analogous to bone mineral

Methodology Applied

Scientific EffectIon exchange: Ion Exchange

Implementation Method 2

the ceramic component releases calcium and silicate or calcium and borate ions which facilitate the differentiation and proliferation of osteoblasts

Methodology Applied

Scientific EffectDissolution: Hydrolysis

Data Source

PatentUS9199032B2System and kit for delivering collagen bioglass composite bone grafting materials for regenerating hard tissues

Publication Date: 2015.12.01 NOVABONE PRODUCTS LLC

AI summary

Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for regenerating bone comprising collagen and bioactive glass are provided.