Collagen Composite Bone Implant with Inhomogeneous Distribution

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Solution Overview

Problem

Current methods for bone regeneration and preservation in alveolar spaces or bone defects, such as after tooth extraction, often result in undesirable bone loss due to inflammation and impaired wound healing, and existing implants can cause further complications with ingrowth issues and high production costs.

Innovation Solution

A composite shaped body made of collagen material with inhomogeneously distributed bone replacement material, allowing for targeted mechanical support and reduced load on the bone defect site, promoting natural bone regeneration and stabilization while minimizing tissue damage during insertion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If bone replacement material is homogeneously distributed in the shaped body, then mechanical support is uniform throughout, but the load on the bone defect site is excessive and vascularization is hindered

Engineering Contradiction:
Improvemechanical supportVSAvoidexcessive load and hindered vascularization
Core Design Contradiction:
StrengthVSObject-generated harmful factors

Solution Approach 1:

The patent applies local quality by creating zones with different bone replacement material concentrations. The first zone has a first concentration level providing mechanical support, while the second zone has a second concentration level that is lower, allowing better vascularization and reduced load. This spatial variation in material distribution resolves the contradiction between needing mechanical strength and avoiding excessive load.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The shaped body is segmented into multiple zones with different bone replacement material concentrations. The first zone provides mechanical support where needed, while the second zone facilitates vascularization and reduces overall load. This segmentation allows different regions to perform different functions simultaneously.

Inventive Principle:
Principle #1Segmentation

2Strength

If the shaped body is made of hard and inflexible bone replacement material, then mechanical stabilization is achieved, but additional injuries occur during insertion into the alveolus

Engineering Contradiction:
Improvemechanical stabilizationVSAvoidadditional injuries during insertion
Core Design Contradiction:
StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent uses composite materials combining collagen material with bone replacement material. The collagen material provides flexibility and softness, preventing additional injuries during insertion, while the bone replacement material provides mechanical stabilization. This composite structure resolves the contradiction between hardness for stabilization and softness for easy insertion.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The patent changes the mechanical parameters of the shaped body by incorporating collagen material, which alters the rigidity and flexibility characteristics. This parameter change allows the shaped body to be soft enough for easy insertion while maintaining sufficient mechanical support through the bone replacement material.

Inventive Principle:
Principle #35Parameter changes

3Ease of operation

If collagen material is used as the base body, then compressibility and ease of insertion are improved, but mechanical stabilization is reduced

Engineering Contradiction:
Improvecompressibility and ease of insertionVSAvoidmechanical stabilization
Core Design Contradiction:
Ease of operationVSStrength

Solution Approach 1:

The patent combines collagen material with bone replacement material to create a composite structure. The collagen material provides compressibility and ease of insertion, while the bone replacement material provides mechanical stabilization. The synergistic combination resolves the contradiction between ease of operation and mechanical strength.

Inventive Principle:
Principle #40Composite materials

4Duration of action of stationary object

If bone replacement material is used to stabilize the bone defect rapidly, then mechanical support is provided, but complete bone regeneration is delayed due to reduced vascularization

Engineering Contradiction:
Improverapid stabilizationVSAvoiddelayed complete bone regeneration
Core Design Contradiction:
Duration of action of stationary objectVSDuration of action of moving object

Solution Approach 1:

The patent creates different zones with different bone replacement material concentrations. The first zone provides rapid mechanical stabilization, while the second zone with lower concentration promotes vascularization and complete bone regeneration. This local quality differentiation allows both rapid stabilization and complete regeneration to occur in different regions.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The shaped body is segmented into zones with different functional characteristics. One zone provides rapid stabilization through higher bone replacement material content, while another zone facilitates complete regeneration through lower material content and better vascularization. This segmentation enables simultaneous achievement of both objectives.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite body facilitates improved wound healing and bone regeneration by providing a regenerative matrix that supports physiological bone growth, reduces bone loss, and allows for easier implant integration with reduced treatment time and cost.

Implementation Method 1

a composite material with at least a first material component in the form of a collagen material and a second material component in the form of a bone replacement material

Methodology Applied
Scientific EffectComposite materials: Composite Materials

Implementation Method 2

The shaped body is compressible and has a compression modulus of at most 1.0 MPa when compressed by up to 40% of its original volume

Methodology Applied
Scientific EffectCompression: Compression

Data Source

PatentEP2572738B8Mould with composite material containing collagen for insertion in a bone defect point
Publication Date: 2018.02.21 RESORBA MEDICAL GMBH

AI summary

The shaped component (1) is intended for insertion into an alveolar space or other bone defect site. The shaped component (1) is composed of a composite material comprising at least a first material component in the form of a collagen material and a second material component in the form of a bone substitute material. The collagen material forms a matrix in which the bone substitute material is inhomogeneously embedded, such that the local collagen content, based on any partial volume of 30 mm³, is at least 10% everywhere, and the global collagen content, based on the total volume, is between 30% and 95%. The shaped component (1) is compressible.A local bone substitute material fraction, based on a partial volume of 30 mm3, has its maximum value at a marginal surface (3) and decreases from the marginal surface (3) inwards, whereby a bone substitute material zone (2) extends from the marginal surface (3) inwards.