Collagen-Bone Putty for Retention and Osteogenesis

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Solution Overview

Problem

Conventional carrier-based bone particle compositions using blood as a vehicle face challenges such as inconvenience in mixing at the surgical site, lack of retention due to low viscosity, and potential immunologic responses, while alternative compositions may delay bone formation or require removal of intraosseous lipid.

Innovation Solution

A collagen-demineralized bone composition where demineralized or partially demineralized bone particles are suspended in extracted bone collagen, processed using elevated temperature and pressure to create a viscous mixture that can be freeze-dried or reconstituted for surgical use, minimizing antigenicity and optimizing osteogenic potential.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If blood is used as a carrier for bone particles, then the composition can be easily prepared, but the viscosity is low resulting in poor retention at the application site

Engineering Contradiction:

Improveease of preparationVSAvoidretention capability

Core Design Contradiction:

Ease of manufactureVSStrength

Solution Approach 1:

The patent changes the physical-chemical parameters of the carrier by using extracted bone collagen instead of blood. The bone collagen provides high viscosity and gel-forming properties that dramatically improve retention capability while maintaining ease of preparation through a standardized extraction process from bone particles.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses bone collagen extracted from the same bone particles being transported, creating a homogeneous system where the carrier and cargo share the same biological origin. This homogeneity improves both preparation simplicity and retention, as the collagen naturally adheres to and retains the bone particles at the application site.

Inventive Principle:

Principle #33Homogeneity

2Ease of manufacture

If blood is used as a carrier, then the composition can be prepared readily, but immunologic responses may occur

Engineering Contradiction:

Improveease of preparationVSAvoidimmunologic response

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and purifies bone collagen from bone particles, separating it from blood and other immunogenic components. This extracted collagen serves as the carrier, eliminating the immunologic responses associated with blood-based carriers while maintaining ease of preparation through the extraction process.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The bone particles themselves serve as the source of the carrier material through self-extraction of collagen. This self-service approach eliminates the need for external blood products or synthetic carriers, reducing immunologic risks while simplifying preparation to a single extraction and mixing step.

Inventive Principle:

Principle #25Self-service

3Reliability

If demineralized bone particles are used, then osteogenic potential is enhanced, but the particles lack structural integrity for effective delivery

Engineering Contradiction:

Improveosteogenic potentialVSAvoidstructural integrity

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent uses extracted bone collagen as an intermediary carrier that bridges the contradiction between demineralized particles (high osteogenic potential) and structural integrity needs. The collagen provides the mechanical strength and structural framework for effective delivery, while the demineralized bone particles maintain their osteogenic properties within this protective matrix.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The collagen-demineralized bone composition effectively retains bone particles at the application site, reduces immunologic responses, and enhances bone formation by maintaining the osteogenic potential of bone morphogenetic proteins, facilitating efficient delivery and integration.

Implementation Method 1

extracting bone collagen from the bone particles to form an extraction mixture of the bone particles and bone collagen

Methodology Applied

Scientific EffectExtraction:

Implementation Method 2

The resulting viscous supernatant is cooled and mixed with non-demineralized or demineralized bone particles to produce a gel or putty-like material

Methodology Applied

Scientific EffectCooling: Cooling

Implementation Method 3

The bone composition may be freeze-dried, hypothermically dehydrated, chemical dehydrated, or desiccated

Methodology Applied

Scientific EffectFreeze-drying: Freeze Drying

Data Source

PatentUS10549011B2Bone putty and gel systems and methods

Publication Date: 2020.02.04 OSTEOLIFE BIOMEDICAL LLC

AI summary

A collagen-bone composition may include bone collagen and bone particles. The collagen may be in the form of a collagen suspension and the bone particles may be demineralized bone particles retained in collagen suspension. The composition may be prepared from pressure and thermal treatment of dry demineralized bone particles contacted with an aqueous medium to produce a viscous gel-like fluid. The fluid may include the collagen extracted from the demineralized bone particles. Addition of particulate bone may be used to increase the consistency of the composition, which may convert it into a paste or putty. The paste or putty may be suitable for ejection from a syringe. The collagen-bone composition may be preserved by freeze-drying or preferably by hypothermic dehydration. On reconstitution with aqueous medium, the preserved material may resume its original shape and properties.