Bioresorbable Collagen Casing for Bone Graft Containment
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Solution Overview
Problem
Existing bone grafting materials, particularly in particulate form, face challenges in forming larger prostheses due to handling issues and dilution by carriers, which reduces their effectiveness, and existing mesh pouches have limitations in retaining surface area and allowing access to bodily fluids and osteogenic cells.
Innovation Solution
Bioresorbable collagen casings with both micropores and macropores that can contain various bone-grafting materials, allowing osteogenic cells and bodily fluids to pass through, and can be pre-filled or filled during implantation, providing adaptability in shape and size for specific applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If putties are used to address handling issues with particulate DBM, then handling is improved, but the amount of carrier increases (about 60% in some cases) which dilutes the amount of DBM and reduces its effectiveness
Solution Approach 1:
A collagen-based putty carrier serves as an intermediary substance that enables handling of particulate DBM while maintaining high DBM concentration. The collagen putty acts as a mediating material that provides structural support and handling properties without requiring excessive carrier volume, thus avoiding dilution of the active DBM component.
Solution Approach 2:
The collagen putty carrier changes the physical parameters of the DBM mixture by providing a cohesive matrix that binds particulate DBM. This parameter change allows the mixture to transition from loose particles to a handleable putty form while maintaining high DBM content, eliminating the need for excessive carrier materials.
2Shape
If mesh pouches are used to provide containment and shape to particulate bone grafting material, then containment is improved, but access for bodily fluids and osteogenic cells to the grafting material is limited
Solution Approach 1:
The collagen putty carrier incorporates a porous structure that allows bodily fluids and osteogenic cells to penetrate and access the particulate DBM throughout the material. This porosity ensures reliable biological access while the collagen matrix maintains the structural containment and shape necessary for surgical application.
Solution Approach 2:
The system uses a composite structure combining collagen putty with particulate DBM. The collagen matrix provides containment and shape, while its inherent porosity and biocompatibility allow fluid and cell penetration. This composite approach resolves the contradiction by integrating both structural and biological access requirements into a single material system.
3Area of stationary object
If particulate form is used for bone grafting materials, then surface area is increased improving osteoinductivity, but handling and forming larger prostheses becomes difficult
Solution Approach 1:
The invention merges the advantages of particulate DBM (high surface area) with the handling properties of collagen putty. By combining these two forms, the system maintains the high surface area of particles for osteoinductivity while the collagen matrix provides cohesive handling properties that enable formation of larger prostheses and structures.
Solution Approach 2:
The collagen putty acts as an intermediary that binds particulate DBM together, enabling the formation of larger prosthetic structures. The putty carrier provides structural continuity between particles, allowing them to be shaped into larger forms while maintaining the high surface area of individual particles for biological activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The collagen casings effectively contain and deliver bone-grafting materials while maintaining surface area advantages, allowing for improved osteoinductivity and osteoconductivity, facilitating better bone growth and reducing the need for carriers, thus enhancing the effectiveness of bone grafting procedures.
Implementation Method 1
allowing osteogenic cells and bodily fluids to pass through
Implementation Method 2
The casing may be constructed of collagen providing advantages over existing mesh pouches constructed from absorbable polymers
Implementation Method 3
the degraded material does not require clearance from the body
Implementation Method 4
Bioresorbable casings having both micropores and macropores suitable for containing a variety of bone-grafting materials
Data Source
AI summary
The present invention relates to methods for bioresorbable and biodegradable casings having both micropores and macropores for providing shape, structure and containment to different bone grafting materials. Kits and methods of use are also described.