Collagen Elastin Scaffold Bone Adhesion

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Solution Overview

Problem

Current methods for cartilage replacement in joints are invasive, have long recovery times, and often fail to adhere properly to bone, with existing scaffolds posing clinical risks and not effectively addressing the need for efficient, long-lasting cartilage repair.

Innovation Solution

A composition comprising Type II collagen, elastin peptide, and calcium gluconate combined with a fibrin sealant to form a collagen scaffold that can be injected into the joint to replace damaged cartilage, providing a scaffold that adheres to the bone and supports chondrocyte growth.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If joint replacement surgery with artificial implants is performed, then motion is restored and pain is reduced, but recovery time is long and risk of dislocation/fracturing/erosion increases

Engineering Contradiction:

Improvejoint function restorationVSAvoidrecovery time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The invention changes the material parameters by using biocompatible collagen and elastin peptides instead of traditional metal or plastic implants, creating a scaffold that degrades over time as natural cartilage forms, thereby reducing long-term complications and recovery time

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The scaffold enables self-service by providing a temporary structure that supports natural cartilage regeneration, allowing the body's own cellular processes to restore the joint without requiring permanent artificial components that can fail

Inventive Principle:

Principle #25Self-service

2Quantity of substance

If chondrocytes are injected into the joint, then cartilage cell replacement is achieved, but the scaffold does not adhere to bone and cell proliferation is not ensured

Engineering Contradiction:

Improvechondrocyte placementVSAvoidscaffold adhesion to bone

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The invention uses composite materials combining type II collagen with elastin peptides and divalent cations, creating a multi-component scaffold that provides both structural support and biochemical signals for bone adhesion and chondrocyte proliferation

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The elastin peptide acts as an intermediary between the collagen scaffold and bone tissue, facilitating adhesion through specific biochemical interactions while also supporting chondrocyte attachment and proliferation

Inventive Principle:

Principle #24Intermediary (Mediator)

3Shape

If artificial compounds are used to form scaffolds, then cartilage structure is mimicked, but clinical problems and adverse side effects occur

Engineering Contradiction:

Improvecartilage structure mimicryVSAvoidclinical risks and side effects

Core Design Contradiction:

ShapeVSObject-affected harmful factors

Solution Approach 1:

The invention changes the chemical parameters by using natural biocompatible materials (collagen and elastin peptides) instead of synthetic compounds, maintaining the necessary structural properties while eliminating adverse immunogenic responses and clinical side effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The scaffold uses homogeneous natural biomaterials that match the biochemical composition of native cartilage, creating a biocompatible environment that reduces rejection risks and adverse reactions while maintaining structural integrity

Inventive Principle:

Principle #33Homogeneity

4Quantity of substance

If traditional scaffolds are used, then cartilage replacement is attempted, but mechanism to adhere scaffold to bone is not addressed

Engineering Contradiction:

Improvescaffold materialVSAvoidscaffold-bone adhesion

Core Design Contradiction:

Quantity of substanceVSStrength

Solution Approach 1:

The elastin peptide serves as a biochemical intermediary that mediates adhesion between the collagen scaffold and bone tissue, providing specific binding sites that strengthen the interface and ensure stable anchoring

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The composite of type II collagen and elastin peptides creates a multi-functional material that simultaneously provides structural framework and adhesion properties, combining the benefits of both materials for enhanced scaffold-bone bonding

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The collagen scaffold effectively adheres to the bone and supports cartilage repair, offering a minimally invasive, long-lasting solution for cartilage replacement with improved stability and reduced clinical risks compared to traditional methods.

Implementation Method 1

The composition may further comprise a solvent and a crosslinking agent that crosslinks the collagen and the elastin peptide

Methodology Applied

Scientific EffectCrosslinking: Chemical Bonding

Implementation Method 2

mixing the composition with a fibrin sealant to form a collagen scaffold

Methodology Applied

Scientific EffectFibrin formation: Coagulation

Data Source

PatentEP3946264B1Cartilage replacement compositions and methods

Publication Date: 2023.09.27 INNOVATIVE ORTHOPEDICS LLC

Figure 1A~1B
Figure 1C~1D
Figure 2A~2B

AI summary

Described are compositions and methods for cartilage replacement. Also described are collagen scaffolds comprising the composition described herein.