Multi-Layered Collagen Biomaterial for Hernia Repair
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Solution Overview
Problem
Current hernia repair materials, both synthetic and biologic, face challenges such as high recurrence rates, infection risks, adhesion formation, and donor site morbidity, necessitating the development of a material that combines the benefits of biologic meshes with the biomechanical properties of synthetic meshes.
Innovation Solution
A multi-layered, naturally occurring biomaterial comprising predominantly type I collagen fibers, derived from mammalian or non-human sources, is developed. This biomaterial is designed to mimic the anatomical and biomechanical properties of natural tissues, offering enhanced strength, flexibility, and integration with the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If synthetic meshes (heavyweight) are used for hernia repair, then tensile strength is improved, but flexibility and compliance with the body wall deteriorate
Solution Approach 1:
The patent applies parameter changes by transitioning from heavyweight to lightweight synthetic meshes, modifying the material density and tensile strength parameters to achieve better flexibility and compliance while maintaining adequate strength for hernia repair
Solution Approach 2:
The patent employs composite materials by combining synthetic mesh components with biologic components (such as porcine small intestinal submucosa or human amnion), creating a hybrid material that integrates the strength and durability of synthetics with the biocompatibility and flexibility of biologics
2Adaptability or versatility
If lightweight synthetic meshes are used, then flexibility and compliance are improved, but tensile strength deteriorates
Solution Approach 1:
The patent uses composite materials to combine lightweight synthetic mesh with biologic components, achieving both the desired flexibility and compliance of lightweight materials while compensating for reduced tensile strength through the reinforcing biologic layer
3Object-affected harmful factors
If biologic meshes are used, then infection risk and adhesion formation are reduced, but hernia recurrence rate increases
Solution Approach 1:
The patent applies composite materials by layering biologic components (which reduce infection and adhesion) with synthetic mesh components (which provide structural support and prevent recurrence), creating a hybrid construct that delivers both benefits
Solution Approach 2:
The patent merges biologic and synthetic materials into a single integrated repair solution, combining the biocompatibility advantages of biologics with the mechanical reliability of synthetics to achieve both reduced complications and low recurrence rates
4Adaptability or versatility
If autologous fascia lata is used, then tissue compatibility is improved, but donor site morbidity and surgical complexity increase
Solution Approach 1:
The patent extracts the beneficial property of tissue compatibility from autologous tissue by using biologic meshes derived from allogenic or xenogenic sources (such as porcine or bovine tissues) that have been processed to eliminate immunogenicity while retaining biocompatibility, thereby avoiding the need for complex donor site harvesting procedures
Data Source
AI summary
Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.