Collagen-Hydroxyapatite Compositions for Demineralized Dentin Repair

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Solution Overview

Problem

Existing dental compositions fail to effectively repair demineralized dentin at advanced stages of caries disease, lacking the necessary composition and structure to promote dentin regeneration and adhesion.

Innovation Solution

A composition comprising uncrosslinked and non-denatured collagen microparticles with over 90% collagen, biomimetic hydroxyapatite or amorphous calcium phosphate, and a physiologically compatible aqueous solvent, which mimics dentin structure for effective repair and regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional surgical model approach is used for dental care, then cavity restoration can be achieved, but tooth structure is progressively weakened and extracted

Engineering Contradiction:

Improvecavity restorationVSAvoidtooth structure

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The patent converts the harmful effect of demineralization into a beneficial remineralization process by applying a composition containing hydroxyapatite and collagen that promotes natural tooth repair and regeneration, transforming the destructive caries process into a restorative one

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent changes the chemical and physical parameters of the dentin repair composition by controlling the size (5 nm or less), shape, and concentration of hydroxyapatite particles, as well as the collagen content and molecular weight, to optimize the material's ability to promote dentin regeneration while maintaining tooth structural integrity

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If hydroxyapatite particles are used in bone repair compositions, then bone implant material can be formed, but the composition lacks sufficient collagen concentration to achieve liquid crystal organization

Engineering Contradiction:

Improvehydroxyapatite particlesVSAvoidcollagen concentration

Core Design Contradiction:

Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent optimizes the concentration and molecular weight parameters of collagen in the composition to achieve proper liquid crystal organization, which is essential for the material's ability to mimic natural dentin structure and promote regeneration

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If collagen is replaced by gelatin or prepared at temperatures above 40°C, then processing flexibility is improved, but collagen is irreversibly denatured to gelatinized material

Engineering Contradiction:

Improveprocessing flexibilityVSAvoidcollagen structure

Core Design Contradiction:

Ease of manufactureVSStability of the object's composition

Solution Approach 1:

The patent carefully controls the preparation temperature parameter to remain below 40°C to prevent collagen denaturation, while still achieving proper material formation through controlled crystallization and self-assembly processes

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses uncrosslinked and non-denatured collagen microparticles that maintain their native structure and biological activity, providing a temporary but functional scaffold that promotes natural tooth repair rather than requiring permanent synthetic substitutes

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

4Stability of the object's composition

If compositions are dried before use to form powder, then storage stability is improved, but collagen turns into fragile sponge-like material instead of hydrogel with striated fibrils

Engineering Contradiction:

Improvestorage stabilityVSAvoidcollagen structure

Core Design Contradiction:

Stability of the object's compositionVSShape

Solution Approach 1:

The patent performs preliminary formation of collagen microparticles with proper striated fibril structure before final use, maintaining the hydrogel morphology and biological activity while ensuring storage stability through controlled particle formation and stabilization

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition serves as a biomimetic scaffold for dentin repair, promoting adhesion and regeneration by mimicking dentin structure, suitable for injection or implantation to repair demineralized dentin.

Implementation Method 1

Methodology Applied

Scientific EffectBiomimetic structure:

Data Source

PatentUS20250255782A1Compositions for use as dentine substitute

Publication Date: 2025.08.14 UNIVERSITY OF GENEVA

AI summary

The present disclosure relates to compositions comprising collagen microparticles comprising more than 90% by weight of collagen, biomimetic hydroxyapatite or biomimetic hydroxyapatite precursors and a physiologically compatible aqueous solvent for use in dentine repair.