Multi-Layer Collagen Membrane for Tissue Regeneration
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Solution Overview
Problem
Current tissue regeneration and repair methods lack effective alloplastic or xenogeneic substitute graft materials for widespread application in surgical procedures, particularly for skin and mucous membrane reconstruction.
Innovation Solution
A resorbable multi-layer structure comprising a purified collagen barrier sheet material with a smooth outer face and a fibrous inner face, combined with a collagen sponge matrix layer that is resorbed faster than the barrier sheet, promoting tissue regeneration and repair by facilitating cell growth and tissue healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single-layer collagen membrane is used for tissue regeneration, then the structure is simple and easy to manufacture, but the ability to promote effective tissue regeneration and repair is insufficient
Solution Approach 1:
The collagen membrane is divided into two distinct layers: a barrier layer providing structural support and a matrix layer promoting cell proliferation. This segmentation allows each layer to perform its specific function optimally, improving tissue regeneration effectiveness without creating an overly complex structure.
Solution Approach 2:
The invention uses a composite structure combining a barrier layer with a matrix layer of different collagen properties. The barrier layer provides mechanical strength and integrity, while the matrix layer enhances cell proliferation and tissue regeneration, creating a synergistic effect that improves overall performance.
2Productivity
If a fast-resorbing collagen material is used, then tissue regeneration is promoted quickly, but the structural support during healing is insufficient
Solution Approach 1:
The membrane is segmented into a barrier layer that maintains structural support and a matrix layer that resorbs quickly to promote cell proliferation. This division allows the barrier layer to provide the necessary strength during healing while the matrix layer enables fast tissue regeneration through its rapid resorption and subsequent cell infiltration.
Solution Approach 2:
Different regions of the membrane have different functional properties: the barrier layer is designed for structural integrity and longevity, while the matrix layer is designed for rapid resorption and cell proliferation. This local differentiation of material properties allows simultaneous achievement of structural support and fast regeneration.
3Duration of action of stationary object
If a slow-resorbing collagen material is used, then structural support is maintained longer, but tissue regeneration is delayed
Solution Approach 1:
The membrane structure separates the functions of structural support and tissue regeneration into two layers. The barrier layer provides long-lasting structural support, while the matrix layer is designed to resorb quickly to stimulate cell proliferation and accelerate tissue regeneration, resolving the contradiction between support duration and regeneration rate.
Solution Approach 2:
The barrier layer is formulated with properties for long-term structural support, while the matrix layer has properties for rapid resorption and cell proliferation. This local differentiation of material properties allows the membrane to simultaneously provide prolonged support and accelerate regeneration.
4Adaptability or versatility
If alloplastic or xenogeneic substitute graft materials are used, then the application range is expanded, but the effectiveness in promoting tissue regeneration is insufficient
Solution Approach 1:
The invention modifies the material parameters of collagen membranes by creating a two-layer structure with different collagen compositions and degradation rates. This parameter change enables the membrane to simultaneously achieve broad applicability across different tissue types and effective tissue regeneration promotion.
Solution Approach 2:
The composite structure combines a barrier layer with a matrix layer that have complementary properties. This composite approach enhances the overall effectiveness of the graft material in promoting tissue regeneration while maintaining versatility across different application sites and tissue types.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-layer structure effectively promotes tissue regeneration and repair by allowing the matrix layer to be resorbed at a faster rate than the barrier sheet, enhancing tissue healing and grafting processes, with the barrier sheet providing prolonged support during the healing process.
Implementation Method 1
The matrix layer of collagen sponge material is resorbed by the body at a faster rate than the collagen sheet material
Data Source
AI summary
Tissue regeneration or grafting is promoted utilizing a structure including a multi-layer sheet of collagen membrane material which includes a purified collagen barrier sheet material derived from natural collagen-containing tissue, the barrier sheet material including a barrier layer with an outer smooth barrier face and a fibrous face opposite the smooth barrier face. The structure further includes a matrix layer of collagen sponge material adjacent to the fibrous face. The matrix layer of collagen sponge material is resorbed by a body of a subject at a substantially faster rate than the barrier sheet material.