Collagen Microfiber Hemostat for Sprayable Rapid Bleeding Control
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Solution Overview
Problem
Existing collagen hemostatic materials, particularly collagen fibers and powders, face challenges in achieving rapid hemostasis due to size limitations, aggregation issues, and denaturation during processing, which affect their dispersibility and biological activity.
Innovation Solution
A collagen microfiber hemostatic material is prepared through high-speed shearing and freeze-drying, with controlled micron-sized fibers and efficient loading of procoagulant active ingredients using linking molecules, enabling rapid adhesion and precise application via spraying.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If collagen fibers are used in large size (centimeter level), then they have good adhesion properties, but they gather into clusters and cannot be dispersed for spraying application
Solution Approach 1:
The patent segments collagen fibers into microfiber dimensions (1-100 μm) through high-speed shearing, transforming continuous large-size fibers into discrete microfibers that can be uniformly dispersed in suspension while maintaining adhesion capability. This segmentation enables the material to be applied via spraying method.
Solution Approach 2:
The patent transitions from centimeter-level fiber dimensions to micrometer-level dimensions, representing a dimensional change that fundamentally alters the material's behavior. This size reduction enables dispersibility while preserving the essential adhesion function through controlled microfiber morphology.
2Manufacturing precision
If spray drying is used to prepare collagen powder, then particle size can be controlled, but the high temperature (100-130°C) causes collagen denaturation and loss of biological activity
Solution Approach 1:
The patent changes the processing parameters from high-temperature spray drying to low-temperature high-speed shearing. This parameter change maintains particle size control capability while preserving collagen's biological activity by avoiding denaturation temperatures.
Solution Approach 2:
The patent replaces the thermal field (spray drying at 100-130°C) with a mechanical field (high-speed shearing). This substitution achieves particle size reduction through mechanical force rather than thermal energy, thereby preserving the biological activity of collagen.
3Adaptability or versatility
If high-speed shearing is used to prepare collagen microfiber, then dispersibility and adhesion are improved, but additional processing steps are required
Solution Approach 1:
The patent makes the high-speed shearing device perform multiple functions: fiber segmentation, size control, and suspension preparation. This multi-functionality reduces the need for separate processing steps while achieving the desired microfiber characteristics.
4Speed
If procoagulant active ingredients are loaded on collagen microfiber surface, then hemostatic speed is increased, but manufacturing complexity increases
Solution Approach 1:
The patent performs preliminary loading of procoagulant active ingredients onto the collagen microfiber surface during the manufacturing process. This preliminary action ensures that the hemostatically active components are pre-positioned on the material, enabling rapid hemostatic effect upon application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The collagen microfiber material achieves rapid hemostasis with precise binding to bleeding points, maintaining biological activity and enhancing hemostatic speed, particularly suitable for narrow and high-risk surgical wounds.
Implementation Method 1
obtaining a collagen microfiber raw material by performing high-speed shearing on a solid collagen material
Implementation Method 2
adding linking molecules to the collagen microfiber suspension obtained in step (4)
Implementation Method 3
performing freeze drying on the collagen microfiber suspension obtained in step (5) to obtain a collagen microfiber solid freeze-dried product
Data Source
AI summary
Disclosed in the present invention are a preparation method for and a use method of a collagen microfiber hemostatic material. Collagen microfibers are obtained by performing high-speed shearing on a solid collagen material; after the collagen microfibers are dispersed in an aqueous phase, a procoagulant active ingredient modifies the surfaces of the collagen microfibers by means of linking molecules; and a collagen microfiber hemostatic material is obtained by performing high-speed shearing again after freeze drying. The collagen microfiber material can be prepared simply and efficiently by means of high-speed shearing; the biological activity of the collagen material is maintained as much as possible; and the microfibers have a length range of 10-1000 μm and high dispersibility, thus facilitating spray processing. The procoagulant active ingredient can be efficiently and quantitatively loaded on the surfaces of the collagen microfibers by means of the linking molecules to enhance the hemostatic effect of the collagen microfibers. The collagen microfiber hemostatic material prepared in the present invention can be used for hemostasis of a bleeding wound by means of spraying application, thereby achieving the effect of non-contact fixed-point hemostasis.