Collagen Mixture from Eggshell Membrane and Avian Cartilage

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Solution Overview

Problem

Current methods for producing collagen are expensive, complex, and involve harsh chemicals, which can damage the unique properties of the material, and do not efficiently combine different types of collagen or produce unhydrolyzed eggshell membrane collagen with low molecular weight.

Innovation Solution

A method involving the separation and pulverization of eggshell membranes to create unhydrolyzed eggshell membrane collagen, combined with a process to produce Avian collagen using enzyme treatment and spray drying, resulting in a mixture of Type I, V, X, and II collagen with LOS, reducing the number of steps and avoiding harsh chemicals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional methods are used to produce collagen, then collagen can be obtained, but the process is expensive, complicated, and requires harsh chemicals that damage unique properties

Engineering Contradiction:

Improvequality of collagenVSAvoidcomplexity of production process

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The invention extracts collagen directly from eggshell membranes through a simplified process that removes the need for complex conventional processing steps. The membrane is separated from eggshells, treated with specific enzymes (collagenase, pepsin, or bromelain), and processed into usable collagen forms, eliminating the need for harsh chemicals and complex equipment while maintaining high collagen quality and unique properties

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention uses inexpensive, readily available eggshell membranes as the starting material instead of expensive conventional collagen sources. The process transforms this waste material into high-value collagen products through simple enzymatic treatment, making the production cost-effective and eliminating the need for expensive specialized equipment or harsh chemical reagents

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Productivity

If conventional methods are used to produce collagen, then collagen can be obtained, but the process involves many steps and harsh chemicals

Engineering Contradiction:

Improveefficiency of collagen productionVSAvoidsimplicity of production process

Core Design Contradiction:

ProductivityVSEase of manufacture

Solution Approach 1:

The invention extracts collagen through a streamlined process: separating membranes from eggshells, applying enzymatic treatment (collagenase, pepsin, or bromelain), and processing into final forms. This extraction method eliminates numerous conventional steps and harsh chemical treatments while maintaining high productivity and collagen quality

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention replaces harsh chemical systems with enzymatic systems for collagen extraction. Instead of using strong acids, bases, or organic solvents, the process uses specific enzymes (collagenase, pepsin, bromelain) that selectively break down collagen under mild conditions, simplifying the manufacturing process while improving efficiency and preserving collagen's unique properties

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Manufacturing precision

If eggshell membrane is processed conventionally, then collagen can be obtained, but it is hydrolyzed and has lower molecular weight

Engineering Contradiction:

Improvemolecular weight controlVSAvoidintegrity of collagen structure

Core Design Contradiction:

Manufacturing precisionVSStability of the object's composition

Solution Approach 1:

The invention controls the hydrolysis parameters by using specific enzymes (collagenase, pepsin, or bromelain) at controlled concentrations and temperatures. By adjusting these parameters, the process achieves partial hydrolysis that maintains higher molecular weight collagen while still making it processable and bioavailable, thus balancing manufacturing precision with compositional stability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention produces a composite collagen product that combines partially hydrolyzed collagen fragments with remaining higher molecular weight structures. This composite approach allows the collagen to maintain structural integrity and higher molecular weight characteristics while still being processable and effective for various applications

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method produces a collagen mixture with enhanced molecular weight and fewer processing steps, maintaining the unique properties of collagen, and achieving a blend of collagen types with improved composition and stability.

Implementation Method 1

adding an enzyme mixture to a thawed Avian cartilage to break the cartilage down into liquid form

Methodology Applied

Scientific EffectEnzyme: Enzyme

Implementation Method 2

heating the liquid cartilage to form a layer of liquid digest

Methodology Applied

Scientific EffectHeating: Heating

Implementation Method 3

heating the raised pH level liquid digest to form a partial solid content

Methodology Applied

Scientific EffectEvaporation: Evaporation

Implementation Method 4

spray drying the partial solid content

Methodology Applied

Scientific EffectSpray drying: Evaporation

Data Source

PatentUS9149512B2Collagen mixture and method of making the same

Publication Date: 2015.10.06 R&S INTELLECTUAL PROPERTY GRP INC

AI summary

A collagen mixture having a portion of unhydrolyzed eggshell membrane collagen and Avian collagen.