Collagen Printable Composition for High-Resolution Cell Scaffolds

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Solution Overview

Problem

Current three-dimensional printing systems face challenges in achieving high resolution and compatibility with implanted cells in biological scaffolds, particularly those sourced from suidae family organs, which can be contaminated with original cells and bacteria.

Innovation Solution

A printable composition comprising 0.3-3.0 wt% collagen, 5.0-40.0 wt% monomers, 0.5-2.0 wt% photo initiator, and 0-75 wt% protic solvent, with a resolution of 100 microns or less, a photo speed of 0.1-5 mm (Dp) and 10-100 mJ/cm² (Ec), and a green strength of at least 5 kPa, suitable for 3D printing of cell-receiving scaffolds.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If suidae family sourced organs are de-cellularized and re-cellularized, then functional organ replacement is achieved, but contamination from original animal cells, bacteria, and other contaminants occurs

Engineering Contradiction:

Improvefunctional organ replacement capabilityVSAvoidcontamination from animal cells and bacteria

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and removes the harmful animal cell components from the scaffold material while retaining the beneficial structural framework. The de-cellularization process specifically targets and removes contaminating animal cells, bacteria, and immunogenic components from suidae family sourced organs, leaving a clean acellular scaffold that can be re-cellularized with human cells without contamination risks

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent applies different treatments to different parts of the scaffold material. The extracellular matrix structure is preserved and maintained in its natural state to provide structural support, while the cellular components are selectively removed. This local differentiation allows the scaffold to maintain structural integrity while eliminating contamination

Inventive Principle:

Principle #3Local quality

2Adaptability or versatility

If three-dimensional printing technology is used to produce customized scaffolds, then scaffold customization is achieved, but resolution is insufficient to define walls or fine features within the scaffold

Engineering Contradiction:

Improvescaffold customization capabilityVSAvoidresolution for defining walls and features

Core Design Contradiction:

Adaptability or versatilityVSManufacturing precision

Solution Approach 1:

The patent modifies the physical and chemical parameters of the printable composition to achieve higher resolution. The composition includes collagen at 0.3-3.0 wt% combined with monomers at 5.0-40.0 wt%, creating a formulation that prints at 100 microns or less resolution. The photo initiator concentration (0.5-2.0 wt%) and protic solvent content (0-75 wt%) are optimized to control curing speed and final structure precision, enabling detailed wall and feature definition

Inventive Principle:

Principle #35Parameter changes

3Manufacturing precision

If printable composition with collagen and monomers is used for 3D printing, then high resolution printing is achieved, but structural integrity (green strength) may be compromised

Engineering Contradiction:

Improveprinting resolutionVSAvoidgreen strength of scaffold

Core Design Contradiction:

Manufacturing precisionVSStrength

Solution Approach 1:

The patent creates a composite printable composition combining collagen (0.3-3.0 wt%) with synthetic monomers (5.0-40.0 wt%). The collagen provides structural integrity and green strength, while the monomers enable photocurable properties and high-resolution printing. This composite formulation achieves both 100 micron or less resolution and minimum 5 kPa green strength after drying, resolving the contradiction between precision and strength

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition enables high-resolution, cell-compatible scaffolds with improved cellularization processes, ensuring high green strength and compatibility for cellular growth.

Implementation Method 1

irradiating the deposited layer

Methodology Applied

Scientific EffectPhotopolymerization: Photopolymerisation

Data Source

PatentUS20260109952A1Material and method for producing cell receiving scaffold

Publication Date: 2026.04.23 LUNG BIOTECH PBC

AI summary

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.