Colloid Crosslinking via Solid Particle Phase Transition
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Solution Overview
Problem
Conventional methods for crosslinking hydrogels require dissolving powders in a large aqueous phase, making it difficult to remove dispersing agents, which can cause inflammation and abnormal sensations when used in biomedical applications, especially for injections, due to incomplete removal leading to inflammatory responses and product deposition.
Innovation Solution
A method involving adding solid particles to a colloid solution with a crosslinking agent to convert it into a solid phase, allowing crosslinking to occur, and then removing the solid particles, which are non-toxic and can be absorbed, ensuring a uniform and injectable crosslinked colloid.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If crosslinking is performed in aqueous phase by dissolving powders, then crosslinking reaction can proceed, but dispersing agents cannot be completely removed leading to inflammation and abnormal sensations
Solution Approach 1:
The patent changes the physical state parameter of the crosslinking system from aqueous phase to solid phase. By using solid particles as the medium for crosslinking instead of aqueous solution, the dispersing agents used in conventional aqueous crosslinking are eliminated, thereby removing the source of inflammatory responses and improving biomedical safety.
Solution Approach 2:
The patent utilizes phase transition by conducting the crosslinking reaction in solid phase rather than liquid phase. The colloid solution is converted to solid particles, and the crosslinking agent is added in solid form, allowing the reaction to proceed in solid phase. This phase transition eliminates the need for aqueous dispersing agents that cause inflammation.
2Object-generated harmful factors
If crosslinking is performed in solid phase using solid particles, then dispersing agents can be completely removed, but the process complexity increases
Solution Approach 1:
The patent extracts and eliminates the problematic aqueous phase and dispersing agents from the crosslinking process. By removing the liquid medium and conducting crosslinking directly in solid phase, the harmful dispersing agents are completely removed from the final product, leaving no residues that could cause inflammation.
Solution Approach 2:
The patent uses solid particles as an intermediary medium for the crosslinking reaction. Instead of using aqueous solution as the medium (which requires dispersing agents), solid particles serve as the reaction medium, enabling the crosslinking to proceed without harmful additives while maintaining uniform reaction conditions.
3Quantity of substance
If conventional aqueous crosslinking method is used, then large volume of aqueous phase is required, but this leads to difficulty in removing dispersing agents
Solution Approach 1:
The patent changes the physical state parameter from liquid to solid, eliminating the need for large volumes of aqueous phase. By conducting crosslinking in solid phase, the process requires minimal to no liquid medium, thereby eliminating the associated dispersing agents and simplifying the removal process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves high degree of crosslinking and uniformity, enhancing viscoelastic properties and allowing for safe injection by completely removing the dispersing agents, reducing inflammatory responses and improving the product's stability and injectability.
Implementation Method 1
adding a crosslinking agent and solid particles to the colloid solution, wherein the amount of solid particles added is enough to convert the colloid solution into a solid mixture
Implementation Method 2
a crosslinking reaction proceeds in the solid mixture
Implementation Method 3
removing the solid particles from the solid mixture
Data Source
AI summary
The disclosure provides a method for crosslinking a colloid, including: (a) providing a colloid solution; (b) adding a crosslinking agent and solid particles to the colloid solution, wherein the amount of solid particles added is enough to convert the colloid solution into a solid mixture, and wherein a crosslinking reaction proceeds in the solid mixture; and (c) removing the solid particles from the solid mixture.