Colloidal Antimicrobial Coating for Long-Term Biofouling Prevention

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Solution Overview

Problem

Current antimicrobial and anti-biofouling coatings lack long-term activity and are not suitable for both solid and porous surfaces, particularly in water-exposed applications such as filtration membranes, pipes, and textiles, where biofilm formation and fouling remain significant challenges.

Innovation Solution

Development of colloidal antimicrobial and anti-biofouling coatings comprising hollow round particles with an active polymer shell and an active or inert core, utilizing polymers like polyethylenimine, polyquaternium, and polyhexamethylene biguanide, stabilized with polyvinyl alcohol and polyethylene glycol derivatives, which provide wide-spectrum antimicrobial properties and prevent biofouling.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional antimicrobial coatings are applied to surfaces, then initial antimicrobial activity is achieved, but long-term activity and stability are insufficient

Engineering Contradiction:
Improveduration of antimicrobial activityVSAvoidstability of coating activity
Core Design Contradiction:
Duration of action of moving objectVSReliability

Solution Approach 1:

The patent embeds antimicrobial polymer shells within colloidal particle structures, creating a nested configuration where the active antimicrobial agents are contained within a stable colloidal matrix. This nesting provides both prolonged release (duration) and structural stability (reliability) simultaneously

Inventive Principle:
Principle #7Nested doll (Nesting)

Solution Approach 2:

The invention uses composite colloidal particles combining polymer shells with antimicrobial agents and stabilizing matrices. This composite structure integrates multiple functions: the polymer provides antimicrobial activity, the colloidal structure provides stability, and the composite nature enables both long-term activity and reliability

Inventive Principle:
Principle #40Composite materials

2Adaptability or versatility

If coatings are applied to porous surfaces like filtration membranes, then anti-biofouling protection is needed, but existing coatings are not suitable for both solid and porous surfaces

Engineering Contradiction:
Improveapplicability to different surface typesVSAvoidanti-biofouling performance
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The colloidal particle formulation is designed to function universally on both solid and porous surfaces. The particles can be applied to filtration membranes, solid substrates, and textile fabrics, providing consistent anti-biofouling performance across different surface types through their adaptable colloidal structure

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent specifically addresses porous surfaces by formulating colloidal particles that can penetrate and coat porous structures like filtration membranes effectively. The colloidal nature allows the particles to access and protect the porous internal structure, maintaining anti-biofouling reliability on porous substrates

Inventive Principle:
Principle #31Porous materials

3Reliability

If filtration membranes are used for water purification, then water purification is achieved, but biofouling and microbial colonization reduce performance and operational lifetime

Engineering Contradiction:
Improveperformance of filtration membraneVSAvoidoperational lifetime of membrane
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies antimicrobial colloidal coatings to filtration membranes before they are exposed to contaminated water. This preliminary application of protective agents prevents microbial colonization from occurring in the first place, maintaining performance and extending operational lifetime by addressing the biofouling problem proactively

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The antimicrobial coating provides preliminary anti-action against biofouling by creating a protective barrier that actively prevents microbial attachment and growth on the membrane surface. This preliminary protection counteracts the biofouling tendency before it can degrade membrane performance

Inventive Principle:
Principle #9Preliminary anti-action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The coatings demonstrate sustained bactericidal activity and anti-biofouling performance, maintaining over 99.99% reduction in viable bacteria and preventing biofilm formation on various surfaces, including water filtration membranes and textiles, with stability for extended periods and resistance to water exposure.

Implementation Method 1

the active polymer shell comprises two and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), polyquaternium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMB)

Methodology Applied
Scientific EffectAntimicrobial polymer activity:

Implementation Method 2

the active polymer shell comprises two and more polymers with antimicrobial and anti-biofouling activities

Methodology Applied
Scientific EffectAnti-biofouling activity:

Implementation Method 3

wherein the hollow round colloidal structure further comprises stabilizers and is stable for at least 3 months, and wherein the stabilizers are present in concentrations of 0.01-20% (w/v) of polyvinyl alcohol (PVA)

Methodology Applied
Scientific EffectSteric stabilization:

Data Source

PatentEP3478064B1Colloidal antimicrobial and Anti-biofouling coatings for surfaces
Publication Date: 2024.12.04 THE HONG KONG UNIV OF SCI & TECH
  • EP3478064B1 patent drawingFigure 1
  • EP3478064B1 patent drawingFigure 2
  • EP3478064B1 patent drawingFigure 3a~3d

AI summary

Methods and formulations for antimicrobial and anti-biofouling coating comprising: a hollow round colloidal structure, comprising: an active polymer shell; and an active or inert core; wherein the active polymer shell comprises one and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), functionalized chitosan (CHI), polyquatemium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMD); wherein the active or inert core contains one and more disinfectants, biocides, fragrances or inert solvent; and wherein the hollow round colloidal structure is stable for at least 3 months.