Colloidal Gold Test Strip with Multi-Layer Pad for Trace Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing colloidal gold test strips are not sensitive enough to detect trace or low-concentration samples effectively, requiring improvement for accurate detection results.
Innovation Solution
A test strip design featuring 3 to 8 layers of colloidal gold pads with colored and white edge parts, overlapped to increase sensitivity, and a strap to secure the pads tightly, enhancing the binding of colloidal gold to biological macromolecules for improved detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single layer of colloidal gold pad is used, then the device complexity is reduced, but the measurement precision is insufficient for trace or low-concentration samples
Solution Approach 1:
The colloidal gold pad is divided into multiple layers (3-8 layers) instead of using a single layer. Each layer contains colloidal gold particles that can bind to biological macromolecules, and the multiple layers work together to increase the overall binding capacity and detection sensitivity for trace or low-concentration samples.
Solution Approach 2:
The colloidal gold particles are nested within the matrix of each colloidal gold pad layer, and multiple such layers are stacked together. This nested structure allows the system to maintain a compact form factor while increasing the total amount of colloidal gold available for binding, thereby improving detection sensitivity without proportionally increasing device complexity.
2Measurement precision
If multiple layers of colloidal gold pads are overlapped, then the measurement precision improves, but the manufacturing precision requirements increase
Solution Approach 1:
Multiple colloidal gold pad layers are merged together in an overlapped arrangement, where the colored part of one layer overlaps with the white edge part of adjacent layers. This merging strategy creates a cumulative effect that enhances detection sensitivity while the overlapping design provides a degree of tolerance for manufacturing variations in alignment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The enhanced test strip achieves higher sensitivity and specificity, allowing for reliable detection of trace or low-concentration samples, reducing the risk of false positives and negatives.
Implementation Method 1
enhancing the binding of colloidal gold to biological macromolecules
Data Source
AI summary
A test strip main body with a sample section, colloidal gold pads, an NC film and a water absorption end in sequence; and the colloidal gold pads are of 3 to 8 layers. Compared with the prior art, the test strip has higher sensitivity, which is beneficial to detection of trace or low-concentration samples.