Colloidal Plant Extract Suspension in Acidic Aqueous Media
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Solution Overview
Problem
Current Cannabis plant extract preparations face challenges in stabilizing cannabinoids and oleoresins in aqueous form at high concentrations, relying on carrier oils or starches rather than aqueous solutions, which limits bioavailability and stability.
Innovation Solution
A colloidal suspension method is developed by combining cannabinoids or oleoresins with an emulsifying/stabilizing agent and an acidic aqueous solution of pH less than 7.0, agitated to create a stable mixture that can be used in various forms, including beverages, topicals, and pharmaceuticals, utilizing fruit or vegetable juices as carriers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If carrier oils or starches are used to prepare Cannabis plant extracts, then the extracts can be stabilized and delivered, but the bioavailability is limited and the preparation complexity increases
Solution Approach 1:
The patent introduces an emulsifying agent as an intermediary substance that mediates between the hydrophobic Cannabis extracts and the hydrophilic aqueous solution. This emulsifier forms a stable interface, allowing the extracts to be suspended and stabilized in water-based carriers without requiring complex oil-based preparation systems
Solution Approach 2:
The patent changes the fundamental parameter of the carrier system from oil-based or starch-based to aqueous-based. By adjusting the pH to acidic conditions and using emulsifying agents, the patent transforms the solubility characteristics of Cannabis extracts, enabling them to stabilize in water-based solutions with improved bioavailability
2Reliability
If Cannabis extracts are prepared in aqueous form, then the bioavailability improves, but the stability at high concentrations deteriorates
Solution Approach 1:
The patent creates a composite system combining aqueous solution, emulsifying agents, and Cannabis extracts. This composite formulation allows high concentrations of cannabinoids to remain stably suspended in water-based carriers, preventing phase separation while maintaining improved bioavailability characteristics
Solution Approach 2:
The emulsifying agent serves as a mediator that enables high concentrations of hydrophobic Cannabis extracts to remain stably dispersed in the hydrophilic aqueous environment, preventing precipitation and phase separation while maintaining bioavailability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly enhances bioavailability by maintaining cannabinoids in a suspended state, providing a stable and versatile delivery system for Cannabis plant extracts, suitable for diverse applications and improving therapeutic efficacy.
Implementation Method 1
combining a cannabinoid or an oleoresin, having purity in the range of 0.001% to 100%, an emulsifying or stabilizing agent in sufficient amounts to suspend the cannabinoid or oleoresin within the colloidal mixture to prevent phase separation
Implementation Method 2
create a colloidal mixture wherein the cannabinoid or oleoresin remains suspended throughout the colloidal mixture. In some embodiments, the colloidal mixture is a colloidal suspension or an emulsion
Implementation Method 3
an acidic aqueous solution of pH less than 7.0 sufficient to dissolve the emulsifying or stabilizing agent
Implementation Method 4
The colloidal may be developed by heating to a rolling boil, by agitation, or by sonication
Data Source
AI summary
A colloidal mixture and a method for creating the same is presented comprising combining a cannabinoid or an oleoresin, having purity in the range of 0.001% to 100%, an emulsifying or stabilizing agent in sufficient amounts to suspend the cannabinoid or oleoresin within the colloidal mixture to prevent phase separation wherein the cannabinoid or oleoresin remains suspended throughout the colloidal mixture, and an acidic aqueous solution of pH less than 7.0 sufficient to dissolve the emulsifying or stabilizing agent. The combination is agitated to create a colloidal mixture wherein the cannabinoid or oleoresin remains suspended throughout the colloidal mixture.