Colloidal Silicon Dioxide in Flavored Veterinary Tablets

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Solution Overview

Problem

Flavourings used in veterinary pharmaceutical formulations often deteriorate the pharmaceutical properties of solid drug forms, such as tablet hardness and stability, making them unsuitable for effective administration to animals.

Innovation Solution

Incorporating large amounts of colloidal silicon dioxide (at least 1.5% by weight) into the formulations, which compensates for the adverse effects of flavourings while maintaining their palatability, thereby enhancing the mechanical, storage, and disintegration properties of the tablets.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If flavourings are added to improve animal acceptance, then palatability is improved, but tablet hardness and stability deteriorate

Engineering Contradiction:

Improveanimal acceptanceVSAvoidtablet hardness

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

Colloidal silicon dioxide acts as an intermediary substance that mediates between the flavouring and the tablet matrix. It absorbs the harmful effects of the flavouring on tablet hardness while allowing the flavouring to maintain its palatability function. The colloidal silicon dioxide forms a protective interface that prevents direct negative interaction between flavouring and tablet structure.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the physical-chemical parameters of the formulation by introducing colloidal silicon dioxide, which alters the rheological and mechanical properties of the tablet matrix. This parameter change enables the tablet to maintain hardness despite the presence of flavouring substances, resolving the contradiction between palatability and mechanical strength.

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If flavourings are added to improve animal acceptance, then palatability is improved, but tablet stability deteriorates

Engineering Contradiction:

Improveanimal acceptanceVSAvoidtablet stability

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

Colloidal silicon dioxide serves as a stabilizing intermediary that prevents flavouring-induced degradation of tablet stability. It creates a protective barrier that prevents moisture ingress and maintains the structural integrity of the tablet over time, while allowing the flavouring to remain effective for animal acceptance.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The colloidal silicon dioxide provides beforehand cushioning by pre-establishing a protective network within the tablet matrix that anticipates and prevents stability degradation. This protective structure is built into the formulation before storage, cushioning against future stability issues caused by flavouring presence.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

3Strength

If colloidal silicon dioxide is added to compensate for flavouring effects, then tablet hardness is improved, but formulation complexity increases

Engineering Contradiction:

Improvetablet hardnessVSAvoidformulation complexity

Core Design Contradiction:

StrengthVSDevice complexity

Solution Approach 1:

Colloidal silicon dioxide provides multi-functionality in the formulation: it acts as a hardness agent, a stability enhancer, and a protective barrier against flavouring-induced degradation. This single substance performs multiple functions that would otherwise require multiple separate additives, thereby reducing overall formulation complexity despite the additional component.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The use of colloidal silicon dioxide significantly improves the tablet hardness, stability, and disintegration properties, ensuring good acceptance by animals and maintaining the effectiveness of the active ingredients, even under moist conditions.

Implementation Method 1

The flavourings are intended to facilitate administration of solid drug forms to animals... good storage stability, especially low tendency to absorb water

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Implementation Method 2

the disadvantageous effects of flavouring can be reduced or completely compensated by adding comparatively large amounts of colloidal silicon dioxide

Methodology Applied

Scientific EffectCompensation effect:

Implementation Method 3

good disintegration and release properties... deterioration in release or tablet hardness

Methodology Applied

Scientific EffectDisintegration:

Data Source

PatentUS7858120B2Pharmaceutical formulations containing flavouring substances with improved pharmaceutical properties

Publication Date: 2010.12.28 ELANCO ANIMAL HEALTH GMBH

AI summary

The invention relates to flavoring-containing pharmaceutical formulations with improved pharmaceutical properties, and to process for the production thereof.