Selectively-Releasable Colorant Resin Complex for Antiseptic Solutions
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Solution Overview
Problem
There is a need for colorants in antiseptic solutions to provide precise and uniform colorant content, protect against degradation during sterilization, and detect counterfeit products, API quality, sterility, thermal stress, and impurities effectively.
Innovation Solution
The development of selectively-releasable colorant compositions that form a colorant-resinate complex, where colorant molecules are reversibly bound to a resin, allowing controlled release in response to environmental stimuli, such as pH, temperature, and ionic strength, while maintaining stability and uniformity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If colorant is added to antiseptic solutions, then the product can be visually identified and quality detected, but the colorant precipitates and releases variability increases
Solution Approach 1:
The patent introduces resin particles as an intermediary carrier that binds the colorant molecules. This mediator prevents direct interaction between the colorant and the antiseptic solution components, eliminating precipitation while enabling controlled release through environmental stimuli such as pH changes, ionic strength variations, or temperature shifts.
Solution Approach 2:
The patent utilizes changes in environmental parameters (pH, ionic strength, temperature) to trigger controlled release of the colorant from the resin particles. By designing the resin-colorant complex to respond to specific parameter changes, the system achieves reliable and consistent colorant release only under defined conditions, preventing premature precipitation.
2Reliability
If colorant is exposed to sterilization procedures, then the product achieves sterility, but the colorant degrades
Solution Approach 1:
The patent incorporates the colorant into the resin particles before sterilization. The resin matrix provides preliminary protection to the colorant, shielding it from direct exposure to harsh sterilization conditions such as autoclaving, ethylene oxide, or peroxide treatment. This preliminary protective action prevents degradation while still allowing the sterilization process to achieve sterility.
Solution Approach 2:
The resin particles act as a protective intermediary between the colorant and the sterilization environment. The resin structure withstands the sterilization conditions that would otherwise degrade the colorant, while still permitting the sterilization agents to penetrate and achieve sterility. After sterilization, the colorant remains intact and can be released under controlled conditions.
3Reliability
If colorant is released in compromising environmental chemistries, then the colorant provides detection capability, but the colorant stability decreases
Solution Approach 1:
The resin particles serve as a protective intermediary that shields the colorant from direct contact with compromising environmental chemistries. The resin matrix allows the colorant to maintain stability while still enabling detection capability through controlled release mechanisms that respond to specific environmental stimuli, ensuring the colorant is released only when appropriate conditions are met.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution ensures precise control over colorant release, protects the colorant from environmental chemistries, reduces precipitation, and enables effective detection of counterfeit products and quality assurance, maintaining colorant stability during sterilization and extended shelf life.
Implementation Method 1
resin particles having colorant molecules reversibly bound thereto
Implementation Method 2
The association between the colorant molecules and the resin may include one or more non-covalent interactions, including ionic interactions, hydrogen bonds, halogen bonds, Van de Waals forces, dipole-dipole interactions, dipole-induced dipole interactions, London dispersion forces, π-π interactions, cation-π interactions, hydrophobic interactions
Implementation Method 3
detect counterfeit products, confirm API quality and/or potency, confirm sterility, detect thermal stress, and/or detect impurities in such products
Data Source
AI summary
Selectively-releasable colorant compositions that allow a controllable release of colorant molecules from resin in response to one or more specific environmental stimuli. The selectively-releasable colorant composition may comprise resin particles having colorant molecules reversibly bound thereto. The compositions of the present disclosure may also provide precise and uniform control of free colorant content in an environment and/or protection of the immobilized (i.e., unreleased) colorant from compromising environmental chemistries. The present disclosure also relates to methods of preparing and methods of using the compositions described herein.