Colorimetric Multi-Analyte Sensing With pH-Corrected Concentration Analysis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional measurement methods using colorimetric reagents do not adequately account for the effect of specimen pH on color change, leading to reduced measurement accuracy, and additional pH adjustment layers increase costs without clear correction methods.
Innovation Solution
An analytical system with a sensor and analyzer that uses colorimetric reagents to detect multiple substances, incorporating a color information acquisition part and concentration calculation part to calculate substance concentrations while considering pH influence, utilizing a trained model to improve accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional measurement methods using colorimetric reagents are used, then the measurement process is simple, but the measurement accuracy deteriorates due to uncorrected pH effects on color change
Solution Approach 1:
The sensor is divided into multiple detection parts: a first detection part containing a pH-sensitive colorimetric reagent and a second detection part containing an analyte-specific colorimetric reagent. This segmentation allows independent measurement of pH effects and analyte concentration, enabling correction of pH interference without adding complex external adjustment mechanisms.
Solution Approach 2:
The pH-sensitive colorimetric reagent acts as an intermediary that indirectly measures the pH effect on the analyte-specific reagent. By capturing color information from both detection parts and using machine learning to correlate them, the system mediates the pH interference issue without requiring direct pH measurement or adjustment mechanisms.
2Measurement precision
If additional pH adjustment layers are added to reduce pH effects, then measurement accuracy improves, but device complexity and cost increase
Solution Approach 1:
The sensor performs self-correction by using its own internal pH detection capability. The color information from the pH-sensitive reagent in the first detection part is used to automatically compensate for pH effects on the analyte measurement, eliminating the need for external pH adjustment layers or additional correction mechanisms.
Solution Approach 2:
The first detection part serves multiple functions: it directly measures pH values and simultaneously provides correction data for pH effects on the analyte-specific reagent. This multi-functionality allows a single additional detection part to address both pH measurement and pH interference correction, avoiding the need for separate adjustment mechanisms.
3Measurement precision
If color information from multiple detection parts is used with machine learning, then measurement accuracy improves, but data processing complexity increases
Solution Approach 1:
The system transforms the problem from direct concentration measurement to a parameter transformation problem. By capturing color information (RGB values) from multiple detection parts and using machine learning to transform these parameters into corrected concentration values, the system achieves high accuracy while keeping the physical device simple.
Solution Approach 2:
The patent replaces physical/chemical pH adjustment mechanisms with an information-processing approach. Instead of using mechanical or chemical means to eliminate pH effects, the system uses color information acquisition and machine learning algorithms to computationally correct for pH interference, substituting a simple information processing system for complex physical adjustment mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enhances measurement accuracy by accounting for pH effects on colorimetric reagents, improving concentration calculations through machine learning models.
Implementation Method 1
a measurement method is known in which an image of a test unit, where a plurality of colorimetric reagents are arranged, is captured after the reagents have reacted with an analyte
Implementation Method 2
it is known that a pH value of the solution affects a color change of the colorimetric reagent
Data Source
AI summary
An analytical system includes a sensor having a plurality of detection parts including colorimetric reagents, and configured to detect a plurality of types of substances from a single specimen, and an analyzer having a processor and memory, configured to measure a concentration of at least one substance among the plurality of types of substances, wherein the analyzer includes a color information acquisition part configured to acquire color information indicating colors of the colorimetric reagents contained in the plurality of respective detection parts, and a concentration calculation part configured to calculate the concentration of the one substance by using the color information indicating a color of a colorimetric reagent contained in a detection part for detecting the one substance among the plurality of detection parts, and color information indicating a color of a colorimetric reagent contained in a detection part other than the detection part which detects the one substance.