Bioconjugated Colostrum Hydrocolloid Composite for Skin Penetration
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Solution Overview
Problem
Colostrum-based compositions face challenges due to poor mechanical properties and rapid degradation, limiting their effectiveness in applications such as skin treatments, and existing methods fail to enhance the functional properties of milk proteins for improved viscosity and texture in food products.
Innovation Solution
A bioconjugated composition of colostrum with hydrocolloids like hyaluronic acid, using cross-linking agents to create stable bioconjugates that improve resistance to proteolysis and enhance immunostimulatory and anti-inflammatory effects, facilitating better skin penetration and cellular interaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If powdered colostrum is used in compositions, then the composition can be easily manufactured and stored, but the colostrum proteins rapidly degrade and are quickly cleared in vivo
Solution Approach 1:
The patent applies composite materials by combining colostrum proteins with hydrocolloids (such as hyaluronic acid, xanthan gum, or alginate) to create a bioconjugated composition. This composite structure protects the colostrum proteins from rapid degradation and clearance while maintaining their biological activity, thereby improving stability without sacrificing ease of manufacture
Solution Approach 2:
The patent changes the physical and chemical parameters of colostrum by converting it from a simple powder form to a bioconjugated complex with hydrocolloids. This parameter change includes modifying molecular weight, solubility, and structural organization, which collectively improve the stability and in vivo persistence of colostrum proteins
2Reliability
If colostrum proteins are used for skin treatment, then immunostimulatory and anti-inflammatory effects are achieved, but poor mechanical properties limit their effectiveness
Solution Approach 1:
The patent creates a composite material where colostrum proteins are bioconjugated with hydrocolloids to form a gel-like matrix. This composite structure provides the necessary mechanical strength and structural integrity for topical applications while preserving the immunostimulatory and anti-inflammatory biological activities of the colostrum proteins
Solution Approach 2:
The patent applies local quality by creating regions within the composition where colostrum proteins are concentrated and bioconjugated with hydrocolloids. This localized bioconjugation enhances both the mechanical properties in the gel matrix and the biological activity at the protein-hydrocolloid interface, allowing simultaneous improvement of both properties
3Productivity
If additives are added to modify milk protein functionality, then viscosity and texture are improved, but the use of additives increases and declaration obligations arise
Solution Approach 1:
The patent applies self-service by enabling milk proteins (colostrum) to modify their own functionality through bioconjugation with hydrocolloids. The hydrocolloids act as cross-linking agents that facilitate self-organization of the protein structure, improving viscosity and texture without requiring external additives or complex processing equipment
Solution Approach 2:
The patent uses hydrocolloids as intermediary substances that mediate between the colostrum proteins and the desired functional properties. These hydrocolloids act as natural cross-linking agents that facilitate protein aggregation and gel formation, achieving improved viscosity and texture while avoiding the need for synthetic additives
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bioconjugated composition demonstrates improved stability, enhanced immunostimulatory and anti-inflammatory effects, and superior skin penetration, making it effective for treating various skin conditions and improving food product textures.
Implementation Method 1
using cross-linking agents to create stable bioconjugates
Implementation Method 2
Hyaluronic acid is well known for its large water binding capacity, and hence moisturising properties
Data Source
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AI summary
The present invention relates to a composition comprising colostrum and at least one agent selected from the group of hydrocolloids, wherein said colostrum and at least one agent are bioconjugated. The bioconjugated composition has improved properties compared to colstrum compositions that are not bioconjugated with a hydrocolloid agent. The composition may be used in a variety of settings, for example for topical application for treating skin diseases and skin conditions. The present invention thus also relates to use of the composition and to a method for the preparation of the composition.