Combination Therapy for Gastrointestinal Ulcer Healing
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Solution Overview
Problem
Current treatments for gastrointestinal conditions such as ulcers in mammals, including humans and animals, are often ineffective and require prolonged administration, leading to increased side effects and prolonged recovery times, with existing drugs taking at least four weeks to mitigate symptoms and sometimes requiring ongoing treatment indefinitely.
Innovation Solution
A pharmaceutical composition combining a proton pump inhibitor like omeprazole with an antiparasitic drug like fenbendazole, formulated as a non-solid for oral administration, which provides a synergistic effect reducing gastrointestinal recovery time and allowing for a lower drug dose to achieve similar results, thereby reducing side effects and treatment duration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If single-drug therapy with proton pump inhibitors is used to treat gastrointestinal ulcers, then the treatment duration is prolonged (at least four weeks), but the recovery time remains extended and side effects increase
Solution Approach 1:
The patent combines a proton pump inhibitor (omeprazole) with an antiparasitic drug (fenbendazole) into a single pharmaceutical composition. This combination therapy achieves synergistic effects that accelerate ulcer healing and reduce treatment duration from at least four weeks to potentially one week or less, while maintaining or improving treatment effectiveness compared to single-drug therapy
2Speed
If higher doses of single drugs are administered to improve healing speed, then recovery time may be reduced, but side effects increase
Solution Approach 1:
The patent changes the dosage parameters by using lower individual doses of each drug in combination rather than high doses of a single drug. The synergistic interaction between omeprazole and fenbendazole allows effective ulcer treatment at reduced doses, thereby decreasing side effects while maintaining or improving healing speed
3Reliability
If prolonged administration of single drugs is used to ensure treatment effectiveness, then ulcer healing may be achieved, but recovery time is extended and side effects accumulate
Solution Approach 1:
The combination of proton pump inhibitor and antiparasitic drug creates synergistic effects that enhance treatment effectiveness while shortening the required treatment duration. The dual mechanism of action addresses both acid suppression and potential parasitic contributions to ulcer pathology, achieving reliable healing in less time than single-drug therapy
4Reliability
If ongoing treatment is required indefinitely to maintain ulcer healing, then treatment effectiveness is sustained, but loss of time and accumulation of side effects increase
Solution Approach 1:
The patent modifies the treatment parameter by using a short-course, intensive combination therapy regimen that achieves complete ulcer healing and sustains it without requiring indefinite ongoing treatment. The synergistic combination allows for a finite treatment duration that prevents both time loss and side effect accumulation while maintaining sustained healing
Data Source
AI summary
Described herein are pharmaceutical compositions including a proton pump inhibitor and an antiparasitic drug. In some embodiments, the compositions can be formulated as a non-solid for oral administration. The compositions can be used to treat gastrointestinal conditions. Methods of treatment using the compositions are also described.