Combined Biocide Formulations for Analyte Sensor Enzyme Preservation

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Solution Overview

Problem

Biocides used to preserve analyte detection sensors, such as creatinine detection sensors, can deactivate critical enzymes, leading to rapid loss of sensor functionality and reduced shelf-life.

Innovation Solution

A combination of biocides, such as Onyxide200 and Cl-MlT, is used to form a synergistic biocide formulation that mitigates enzyme inactivation, maintaining sensor functionality and extending its life by reducing the concentration of individual biocides that interact with enzyme sulfhydryl groups.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If a biocide is used to preserve the sensor, then the shelf-life is extended, but the enzyme functionality is deactivated

Engineering Contradiction:

Improvesensor shelf-lifeVSAvoidenzyme functionality

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent combines multiple biocides (e.g., methylisothiazolinone and chloroisothiazolinone) into a single formulation that works synergistically to provide effective preservation while reducing the concentration of individual biocides that can deactivate enzymes. This combining approach allows extended shelf-life through enhanced preservative effect while minimizing harmful impacts on enzyme functionality.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent optimizes the concentration parameters of individual biocides within the formulation. By carefully controlling the relative concentrations of different biocides, the formulation achieves effective preservation at lower individual biocide concentrations, thereby reducing enzyme deactivation while maintaining extended shelf-life.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If the concentration of individual biocides is reduced to protect enzymes, then enzyme activity is maintained, but biocide effectiveness may be compromised

Engineering Contradiction:

Improveenzyme activityVSAvoidbiocide effectiveness

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent merges multiple biocides into a formulation where their combined effect provides sufficient preservation at lower individual concentrations. The synergistic interaction between biocides ensures that reduced concentrations of each individual component remain effective for preservation while being less harmful to enzyme activity.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite biocide formulation combining multiple chemical agents with complementary mechanisms of action. This composite approach provides enhanced overall effectiveness at lower individual concentrations, maintaining biocide effectiveness while reducing enzyme deactivation.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combined biocide formulation effectively reduces contaminant impact, maintaining at least 90% biological activity of the sensor enzymes for over 28 days, thereby enhancing sensor performance and extending its functional life.

Implementation Method 1

via the biocide(s) diffusing through a sensor cover membrane

Methodology Applied

Scientific EffectDiffusion: Diffusion

Data Source

PatentUS20250302043A1Biocide formulations for the preservation of analyte detection sensor(s) and method(s) of use and thereof

Publication Date: 2025.10.02 SIEMENS HEALTHCARE DIAGNOSTICS INC

AI summary

Composition(s), device(s), kit(s), and method(s) for improved biocide formulations that remove contaminants (and the effects related thereto) from at least one analyte detection sensor, while simultaneously preserving and/or extending the functional life of the at least one analyte detection sensor.