Compact assembly for production of medical isotopes via photonuclear reactions

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Solution Overview

Problem

Existing methods for producing medical isotopes are inefficient, costly, and require large amounts of rare or expensive target materials, with current systems being too large and inefficient in terms of beam power and target material usage.

Innovation Solution

A compact assembly integrating a collimator, converter, and target into a single unit with optimized dimensions and cooling configuration, allowing for high power density and minimal target material usage, utilizing photonuclear reactions to produce isotopes efficiently.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If thin converter plates immersed in flowing water are used for cooling, then cooling efficiency is improved, but beam size is limited to large diameters and energy concentration on smaller areas is prevented

Engineering Contradiction:
Improvecooling efficiencyVSAvoidbeam size
Core Design Contradiction:
TemperatureVSArea of moving object

Solution Approach 1:

The converter is divided into multiple thin plates arranged in series, with coolant flowing between them. This segmentation allows efficient heat dissipation while maintaining a compact structure that can handle smaller beam diameters without overheating.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The cooling approach transitions from a single large plate geometry to a multi-plate stacked configuration, utilizing the third dimension (depth/layering) to increase cooling surface area while reducing the required beam diameter and concentrating energy more effectively.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Reliability

If large diameter beams are used to prevent coolant boiling, then cooling reliability is improved, but target material requirements increase to 50-100 grams which is expensive

Engineering Contradiction:
Improvecooling reliabilityVSAvoidtarget material amount
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The system changes the operating parameters by using multiple thin converter plates with controlled coolant flow, enabling reliable cooling at higher power densities. This allows smaller beam diameters and consequently smaller target material quantities (reducing from 50-100 grams to much less) while maintaining cooling reliability.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If high electron beam power is used to produce high flux gamma rays, then isotope production rate is improved, but the electron to gamma conversion process is very inefficient

Engineering Contradiction:
Improveisotope production rateVSAvoidconversion efficiency
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

The converter uses composite construction with thin plates of high atomic number material (such as tantalum or tungsten) arranged in a specific configuration. This composite structure optimizes the electron-to-gamma conversion efficiency while managing heat load, thereby improving both productivity and energy utilization.

Inventive Principle:
Principle #40Composite materials

4Reliability

If more expensive accelerators and large amounts of isotopically enriched target material are used, then desired isotopes can be produced, but production cost increases significantly

Engineering Contradiction:
Improveisotope production capabilityVSAvoidproduction cost
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The system changes key operational parameters including beam energy, beam current, and converter geometry to optimize the photonuclear reaction yield. This allows achieving reliable isotope production using standard accelerators and minimal enriched target material, dramatically reducing production costs compared to conventional methods.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS12456559B2Compact assembly for production of medical isotopes via photonuclear reactions
Publication Date: 2025.10.28 UCHICAGO ARGONNE LLC
  • US12456559B2 patent drawing
  • US12456559B2 patent drawing
  • US12456559B2 patent drawing

AI summary

The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.