Compacted ORC Hemostatic Powder via Ball Milling
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Solution Overview
Problem
Current hemostatic powders made from oxidized regenerated cellulose (ORC) have limitations in terms of aspect ratio, tapped density, and flowability, which affect their efficacy in controlling bleeding during surgical procedures and wound healing.
Innovation Solution
Compacted ORC powders with specific properties are produced through ball milling, roller compaction, or hammer milling, resulting in particles with a low aspect ratio and high tapped density, which can be combined with additives like carboxymethyl cellulose or anti-infective agents to enhance hemostatic properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional ORC powders are used without compaction processing, then the manufacturing process is simple, but the tapped density is low and flowability is poor
Solution Approach 1:
The patent applies parameter changes by modifying the physical state and morphological parameters of ORC particles through compaction processing. Ball milling, roller compaction, and hammer milling transform the particle structure to achieve specific aspect ratios (1:1 to 3:1) and high tapped density (≥0.45 g/cm³), resolving the contradiction between manufacturing simplicity and product quality.
2Ease of operation
If ORC particles have high aspect ratio, then the material retains fibrous structure, but the flowability and hemostatic performance are reduced
Solution Approach 1:
The patent changes the shape parameter of ORC particles by controlling the compaction process to achieve aspect ratios between 1:1 and 3:1. This parameter optimization simultaneously improves flowability (≥7.5 cm/s) and hemostatic performance, resolving the contradiction between maintaining fibrous structure and achieving operational ease.
3Reliability
If ORC powder is compacted to high density, then the hemostatic efficacy is improved, but the particle morphology becomes less controlled
Solution Approach 1:
The patent introduces controlled compaction processing (ball milling, roller compaction, or hammer milling) as an intermediary step between raw ORC production and final application. This intermediary process mediates between the fibrous structure of raw ORC and the high-density requirement for hemostatic efficacy, producing particles with both controlled morphology (aspect ratio 1:1 to 3:1) and high tapped density (≥0.45 g/cm³).
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compacted ORC powders demonstrate superior hemostatic performance with faster blood clotting times and improved flowability, making them more effective in surgical applications and wound treatment.
Implementation Method 1
Compacted ORC powders with specific properties are produced through ball milling, roller compaction, or hammer milling
Implementation Method 2
oxidized regenerated cellulose has long been used as a topical hemostatic wound dressing due to its biodegradability and its bactericidal and hemostatic properties
Data Source
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AI summary
The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.