Compartmented Cryopreservation Container Segregation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for delivering cellularized compositions to the healthcare market are not cost-effective or technologically advanced, and there is a need for convenient preparation and administration of these compositions at the point of care.
Innovation Solution
A cryogenic product with a sealed internal volume containing a cellular composition and a separate porous matrix, stored in separate or integrated compartments within a cryogenic container or bag, which can be mixed upon thawing to form a cellularized matrix composition, facilitating efficient preparation and administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If cellular composition and porous matrix are stored separately in cryogenic container, then composition stability and prevention of premature mixing is improved, but device complexity and preparation time increases
Solution Approach 1:
The cryogenic container is divided into multiple separate compartments, each designed to hold specific components (cellular composition, porous matrix, growth factors) in segregated form. This segmentation maintains composition stability during storage while allowing controlled mixing at administration by simply combining the compartments.
Solution Approach 2:
The patent employs a nested compartment structure where smaller storage compartments are positioned within or alongside each other in the cryogenic container. This nesting approach optimizes space utilization while maintaining physical separation of components, reducing overall device complexity compared to completely separate storage units.
2Manufacturing precision
If multiple components are stored in separate compartments, then mixing control and composition purity is improved, but preparation complexity and time increases
Solution Approach 1:
All components (cellular composition, porous matrix, growth factors) are pre-prepared, pre-tested, and pre-positioned in their respective compartments during manufacturing. This preliminary action ensures that at the point of administration, only a simple combination step is required, maintaining mixing control while minimizing preparation time.
Solution Approach 2:
The patent merges multiple storage compartments into a single integrated cryogenic container system with defined openings between compartments. This allows controlled mixing by simply opening the barriers between compartments, combining the benefits of separate storage (mixing control) with efficient access (reduced preparation time).
3Stability of the object's composition
If cellular composition and solid material are provided as separate non-mixable volumes, then storage stability is improved, but ease of operation and mixing efficiency decreases
Solution Approach 1:
The container design transitions from a static sealed state during storage to a dynamic open state during administration. Defined openings between compartments are sealed during storage to maintain stability, but can be easily opened to allow mixing, providing dynamic adaptability that improves ease of operation without compromising storage stability.
Data Source
AI summary
Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.