Compatible Solutes for Skin Pore Lightening via Carbonylation Control
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Solution Overview
Problem
Age-related skin color changes and uneven skin tone due to the accumulation of carbonylated proteins around skin pores, leading to yellowish or darker areas, are not effectively addressed by existing cosmetic and pharmaceutical treatments.
Innovation Solution
The use of compatible solutes, such as (S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidincarboxylic acid (ectoin) and (S,S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidincarboxylic acid (hydroxyectoin), to reduce protein carbonylation and the accumulation of carbonylated proteins in the stratum corneum, thereby lightening skin pores and improving skin tone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If existing cosmetic and pharmaceutical treatments are used, then general skin care functions are maintained, but age-related skin color changes and uneven skin tone caused by carbonylated proteins are not effectively addressed
Solution Approach 1:
The patent introduces compatible solutes as intermediary substances that mediate between the harmful carbonylation process and the skin proteins. These solutes act as protective agents that intervene in the carbonylation reaction, preventing the formation of carbonylated proteins without directly altering the skin structure or requiring invasive procedures.
Solution Approach 2:
The patent changes the chemical parameter environment by introducing compatible solutes that alter the local chemical conditions around skin proteins. This parameter change prevents the carbonylation reaction from proceeding, thereby addressing skin color changes through biochemical modification rather than physical removal or masking.
2Reliability
If compatible solutes are used, then protein carbonylation is reduced and skin tone is improved, but the mechanism of action differs from conventional treatments
Solution Approach 1:
The patent employs compatible solutes that enable the skin's own protective mechanisms to function more effectively. These solutes support the skin's natural ability to resist oxidative stress and protein damage, allowing the biological system to serve itself in combating carbonylation without requiring complex external intervention systems.
Solution Approach 2:
The patent converts the potentially harmful effect of oxidative stress into a beneficial outcome by using compatible solutes that enhance the skin's resistance to oxidation. The solutes transform the challenging environment of oxidative stress into an opportunity for improved skin protection and healthier skin tone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Compatible solutes effectively minimize oxidative stress, reduce carbonylated protein formation, and promote a more uniform skin color by minimizing the accumulation of carbonylated proteins around skin pores, thus addressing age-related skin color changes and uneven skin tone.
Implementation Method 1
compatible solutes are capable of solving this problem... minimize oxidative stress... reduce carbonylated protein formation
Implementation Method 2
reduce protein carbonylation and the accumulation of carbonylated proteins in the stratum corneum... suppression and/or reduction of the accumulation of carbonylated proteins
Data Source
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AI summary
The present invention relates tothe use of at least one compatible solute and/or its physiologically acceptable salt for countering age-related skin color change or for the suppression and/or reduction of protein carbonylationand/or for the suppression and/or reduction of the accumulation of carbonylated proteins in the stratum corneum. The invention is further directed to formulations comprising at least one compatible solute and/or its physiologically acceptable salt and at least one further skin pore lightening active, as well as a process for preparing such formulation.