Complex-Valued MRI Denoising for Non-Uniform Noise Artifacts

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing denoising algorithms for magnetic resonance imaging (MRI) face challenges in handling non-uniform noise patterns and require high-quality training data, which is difficult to obtain, leading to suboptimal performance, especially in clinical settings with complex noise distributions from multiple coils.

Innovation Solution

A convolutional neural network (CNN) with residual blocks and skip connections is used to denoise MRI images, processing real and imaginary component frames without relying on paired training data, effectively removing resonant and off-resonance artifacts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If filter-based denoising methods (NLM, BM3D) are used, then noise reduction is achieved, but performance deteriorates when dealing with small lesion regions and non-uniform noise patterns

Engineering Contradiction:
Improvedenoising performanceVSAvoidhandling of non-uniform noise patterns
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent transforms the denoising problem from spatial domain filtering to frequency domain processing by changing the parameter space. The complex-valued CNN operates on frequency-domain representations of MRI data, allowing adaptive noise suppression that preserves fine structures better than traditional spatial filters. This parameter transformation enables the system to handle non-uniform noise patterns effectively.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent replaces mechanical filter-based denoising systems with an intelligent neural network system. Instead of using fixed mathematical filters (NLM, BM3D), the system employs a trained complex-valued CNN that learns optimal denoising strategies from training data. This substitution allows the system to adapt to different noise patterns and preserve diagnostic features that mechanical filters would remove.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If deep convolutional neural networks are trained with noise-corrupted images, then denoising capability is improved, but requirement for high-quality training data increases which is difficult to obtain

Engineering Contradiction:
Improvedenoising capabilityVSAvoidavailability of training data
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent implements self-service by enabling the CNN to learn from synthetic training data generated from simulated noise patterns. The system creates its own training dataset by programmatically adding various noise types and levels to synthetic MRI images, eliminating the need for extensive collection of real noisy clinical data. This self-generated training approach makes the system easily deployable without requiring access to large annotated datasets.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent uses copying by creating synthetic training examples that replicate real-world noise conditions. Instead of requiring actual noisy patient data, the system generates copies of synthetic MRI images with added noise patterns that mimic clinical scenarios. These synthetic copies serve as effective training data, allowing the network to learn denoising capabilities without accessing sensitive or difficult-to-obtain real patient data.

Inventive Principle:
Principle #26Copying

3Reliability

If acquisition parameters are changed to improve SNR (more averages, lower bandwidth), then signal-to-noise ratio is improved, but scan time is prolonged

Engineering Contradiction:
Improvesignal-to-noise ratioVSAvoidscan time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies preliminary action by performing denoising operations during the image reconstruction process rather than as a separate post-processing step. The complex-valued CNN is integrated into the reconstruction pipeline, allowing noise suppression to occur concurrently with image formation. This preliminary denoising enables clinical workflows to benefit from improved SNR without adding extra scan time or separate processing steps.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS12521033B2Method and system for low-field MRI denoising with a deep complex-valued convolutional neural network
Publication Date: 2026.01.13 UNIV OF VIRGINIA
  • US12521033B2 patent drawing
  • US12521033B2 patent drawing
  • US12521033B2 patent drawing

AI summary

Blurring and noise artifacts in magnetic resonance (MR) images caused by off-resonant image components may be corrected with convolutional neural networks, particularly feed forward networks with skip connections. Demodulating complex blurred images with off-resonant artifacts at a selected number of frequencies forms a respective real component frame of the MR data and a respective imaginary component frame for each image. A convolutional neural network is used to de-blur the images. The network has a plurality of residual blocks with multiple convolution calculations paired with respective skip connections. The method outputs, from the convolutional neural network, a de-blurred real image frame and a de-blurred imaginary image frame of the MR data for each complex blurred image.