Composite Backing for Transdermal Patches

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Solution Overview

Problem

Transdermal patches face challenges in long-term adhesion to the skin, leading to drug delivery disruptions due to friction, buckling, and skin irritation, particularly for larger patches applied over extended periods, which limits their size and duration of use.

Innovation Solution

A composite backing layer comprising a stretchable polymer fabric or film, an adhesive layer, and an occlusive layer, arranged in contact, which allows for shear yield and movement, reducing friction and maintaining contact with the skin for up to 10 days, even on areas subject to mechanical strain.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If transdermal patches use occlusive backings for prolonged administration, then drug delivery consistency is improved, but patch adhesion deteriorates due to friction and buckling

Engineering Contradiction:

Improvedrug delivery consistencyVSAvoidpatch adhesion

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The backing layer is designed to be dynamically flexible rather than rigid, allowing it to move with skin contours and accommodate mechanical strain. This dynamic flexibility prevents buckling and maintains contact between the occlusive backing and skin surface, resolving the contradiction between maintaining drug delivery consistency and preserving patch adhesion during prolonged wear.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent employs a flexible backing layer constructed from elastomeric materials that can conform to the contours of the skin. This flexible shell structure prevents the patch from buckling under mechanical strain while maintaining the occlusive barrier necessary for consistent drug delivery, directly addressing the adhesion deterioration problem.

Inventive Principle:

Principle #30Flexible shells and thin films

2Ease of operation

If transdermal patches are applied to areas subject to mechanical strain, then ease of operation is improved, but patch adhesion deteriorates due to friction

Engineering Contradiction:

Improveapplication site flexibilityVSAvoidpatch adhesion

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The backing layer incorporates elastomeric materials with dynamic flexibility that allow the patch to move and deform with skin motion in high-strain areas. This dynamic adaptation reduces friction-induced adhesion deterioration while maintaining ease of application on flexible body surfaces.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent uses composite material construction combining elastomeric backing layers with occlusive barriers. This composite structure provides both the flexibility needed for high-strain areas and the structural integrity to maintain adhesion, resolving the contradiction between ease of operation and patch stability.

Inventive Principle:

Principle #40Composite materials

3Duration of action of stationary object

If transdermal patches are made larger for extended wear, then duration of action is improved, but patch adhesion deteriorates due to increased friction and buckling

Engineering Contradiction:

Improvewear timeVSAvoidpatch adhesion

Core Design Contradiction:

Duration of action of stationary objectVSStability of the object's composition

Solution Approach 1:

The flexible backing layer dynamically adapts to skin contours and motion, preventing the buckling that typically causes adhesion failure in large patches. This dynamic flexibility enables larger patch sizes to maintain adhesion throughout extended wear periods, directly resolving the contradiction between duration of action and adhesion stability.

Inventive Principle:

Principle #15Dynamics

4Manufacturing precision

If transdermal patches use rigid backings for structural support, then manufacturing precision is improved, but patch adhesion deteriorates due to inability to conform to skin

Engineering Contradiction:

Improvepatch structure integrityVSAvoidpatch adhesion

Core Design Contradiction:

Manufacturing precisionVSStability of the object's composition

Solution Approach 1:

The patent replaces rigid backings with flexible elastomeric backing layers that can conform to skin contours. This flexible shell maintains sufficient structural integrity for manufacturing precision while enabling the patch to adapt to curved skin surfaces, resolving the contradiction between structure integrity and adhesion.

Inventive Principle:

Principle #30Flexible shells and thin films

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite backing layer enhances the durability and adherence of transdermal patches, enabling longer wear times and reduced skin irritation, allowing for larger patch sizes and consistent drug delivery over extended periods without the need for additional securing measures like medical tape.

Implementation Method 1

A composite backing layer comprising a stretchable polymer fabric or film, an adhesive layer, and an occlusive layer, arranged in contact, which allows for shear yield and movement, reducing friction

Methodology Applied

Scientific EffectElasticity: Elasticity

Data Source

PatentUS12168075B2Systems comprising a composite backing and methods for long term transdermal administration

Publication Date: 2024.12.17 CORIUM INC

AI summary

Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.