Composite Bone Grafts with Consistent Calcium Content
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Solution Overview
Problem
Current bone graft compositions face challenges in achieving consistent calcium content and handling characteristics, making it difficult to produce composite bone graft materials with desired mechanical and biological properties for effective bone repair and fusion procedures.
Innovation Solution
The development of composite bone graft materials involving specific ratios and particle sizes of mineralized and demineralized bone components, combined with adult mesenchymal stem cells, to achieve targeted calcium content and handling characteristics, such as the use of non-demineralized cancellous bone, demineralized cancellous bone, and demineralized cortical bone from the same cadaveric donor, with optional seeding of mesenchymal stem cells on demineralized bone material.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If bone graft compositions use traditional single-source bone material, then the manufacturing process is simple, but the calcium content and handling characteristics are inconsistent
Solution Approach 1:
The bone graft composition is segmented into multiple components: mineralized bone graft material (providing calcium content) and demineralized bone graft material (providing handling characteristics). Each component is processed separately and then combined in specific ratios, allowing independent optimization of calcium content and handling properties that cannot be achieved from a single bone source.
Solution Approach 2:
The invention creates a composite bone graft material combining mineralized and demineralized bone graft materials in predetermined ratios. This composite approach allows the final product to simultaneously achieve consistent calcium content (from mineralized bone) and desired handling characteristics (from demineralized bone), resolving the contradiction between precision and complexity.
2Reliability
If bone graft compositions aim for consistent calcium content, then the biological activity is improved, but the handling characteristics become difficult to control
Solution Approach 1:
The functional requirements are segmented: mineralized bone graft material is responsible for providing consistent calcium content and biological activity, while demineralized bone graft material is responsible for providing desirable handling characteristics. By separating these functions into different components, each can be optimized independently without compromising the other.
Solution Approach 2:
The invention changes the mineralization parameter of the bone graft material by combining fully mineralized bone (high calcium content for biological activity) with demineralized bone (low calcium content for good handling characteristics). This parameter adjustment allows simultaneous achievement of reliable biological activity and ease of handling.
3Ease of operation
If demineralized bone material is used to improve handling characteristics, then the calcium content decreases, but the mechanical strength is reduced
Solution Approach 1:
The invention creates a composite where demineralized bone graft material (providing handling characteristics) is combined with mineralized bone graft material (providing mechanical strength and calcium content). The mineralized component compensates for the strength loss in the demineralized component, allowing the final composite to have both good handling characteristics and adequate mechanical strength.
Solution Approach 2:
Different regions of the bone graft composition have different properties: the mineralized bone provides structural strength and calcium content, while the demineralized bone provides handling characteristics. This local differentiation of material properties allows the composite to simultaneously satisfy requirements for strength and ease of handling that cannot be met by a single uniform material.
Data Source
AI summary
Embodiments of the present invention provides bone graft compositions, and methods for their use and manufacture. A bone graft composition may include a first amount of non-demineralized cancellous bone. The composition may further include a second amount of demineralized cancellous bone. The composition may also include a third amount of demineralized cortical bone. The non-demineralized cancellous bone, the demineralized cancellous bone, and the demineralized cortical bone may be obtained from the same cadaveric donor.