Composite Bone Grafts with Crosslinked Collagen Carriers
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Solution Overview
Problem
Traditional bone grafts, particularly allografts, often lack desired properties such as osteoconduction, osteoinduction, and osteogenesis, and may be difficult to obtain or shape for effective implantation in bone healing procedures.
Innovation Solution
Development of biomaterial compositions combining demineralized bone matrix, bioactive glass, and calcium phosphate, with a carrier like hyaluronic acid or collagen, which are processed to form osteogenic, osteoinductive, and osteoconductive implants that can be molded, freeze-dried, and crosslinked for enhanced bone regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional allograft bone is used, then bone replacement is achieved, but the desired properties of osteoconduction, osteoinduction, and osteogenesis are not exhibited
Solution Approach 1:
The invention combines multiple materials with complementary properties: demineralized bone matrix provides osteoinductive factors, bioactive glass contributes to osteoconduction and bone formation stimulation, and collagen carrier offers structural framework. This composite approach creates a material that exhibits all three desired properties (osteoconduction, osteoinduction, and osteogenesis) simultaneously, resolving the limitation of traditional allografts
2Reliability
If traditional allograft bone is used, then bone replacement is achieved, but the material is difficult to obtain and shape for implantation
Solution Approach 1:
The invention transforms the physical and chemical parameters of bone graft materials through controlled processing. The collagen carrier is crosslinked to achieve desired mechanical strength and structural stability. The material can be formulated in various shapes and sizes suitable for different implantation sites, and processed under controlled conditions to ensure consistency and reproducibility, making it easier to manufacture and implant compared to traditional allografts
3Strength
If biomaterial composition is crosslinked to enhance structural properties, then mechanical strength is improved, but the material may become less biodegradable
Solution Approach 1:
The crosslinking is applied selectively to specific regions and to a controlled degree within the collagen carrier structure. This creates zones of varying crosslink density: highly crosslinked regions provide structural support and mechanical strength where needed, while less crosslinked regions maintain biodegradability and allow for controlled resorption. This local differentiation resolves the contradiction between strength and biodegradability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The biomaterials and implants exhibit improved osteogenic, osteoinductive, and osteoconductive properties, facilitating effective bone healing and repair by providing a scaffold for new bone growth, stimulating cell differentiation, and accelerating the bone formation process.
Implementation Method 1
the hyaluronic acid may be swellable to gel form. For example, the hyaluronic acid may be mixed with water or an acid, such as hydrochloric acid, which causes the carrier to swell in volume
Implementation Method 2
freeze-drying the molded biomaterial composition to form a freeze-dried composition
Implementation Method 3
crosslinking the freeze-dried composition to form a crosslinked composition. Optionally, the method may further include crosslinking the freeze-dried composition with a chemical crosslinking agent (e.g., formaldehyde)
Data Source
AI summary
Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, osteoconductive, and/or osteostimulative properties.